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Glossary entry

English term or phrase:

base changes in the genome

English answer:

point mutations, changes in the bases of the DNA strand

Added to glossary by Jörgen Slet
Nov 5, 2003 10:38
21 yrs ago
English term

base changes

English Science molecular biology
The Escherichia coli tryptophan (trp) reversion system is a microbial assay which measures trp- -> trp+ reversion by chemicals which cause base changes in the genome of the organism.
Responses
5 +2 point mutations
4 +1 base as in bases forming base pairs
3 changes in DNA

Discussion

Non-ProZ.com Nov 5, 2003:
basic or base pair ? What I'm confused is that does it mean "basic" as in fundamenal or "base pair" changes. Do I understand that the suggested answers are divided on this ?

Responses

+2
11 mins
Selected

point mutations

sometimes also referred to as point mutations.

The bases are modified or altered singularly in particular distinct points of the genetic sequence.

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Note added at 2003-11-05 10:54:46 (GMT)
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As I said the term base changes is normally used to refer to point mutations (single individual base changes). Although other, lerger scale mutations or genetic modifications could also be covered by this. I mention this since the trp- to trp+ modification you mention is most likely to be a larger scale event.
Peer comment(s):
agree Anna Haxen : I think we need to establish that "base changes" are changes affecting the four bases entering into the DNA molecule. Here's a good (basic) link:www.geocities.com/CapeCanaveral/ Hangar/4344/section01.html
10 mins
agree DGK T-I : to asker: 'base pair rather than basic'
3 hrs
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "Thanks, all of you."
6 mins

changes in DNA

If I understand what I briefly researched on this phrase, the links seem to indicate that "base changes" are changes in the basic structure, that is, the DNA.

Here are the first ten links.

Labeling, signaling & detection glossary
... detection: The Oxford English Dictionary points out that detecting ... Dr. Carol Fierke,
Professor of Chemistry, University of ... nanomole: Ultrasensitivity glossary. ...
www.genomicglossaries.com/content/ labels_sig_and_detection_gloss.asp - 101k - Nov 3, 2003 - Cached - Similar pages

Pharmacogenomics glossary
... when exposed to a genotoxic agent that causes base changes affecting the ... Toxicology]
International Union of Pure and Applied Chemistry, GLOSSARY FOR CHEMISTS ...
www.genomicglossaries.com/content/pharmacogenomics.asp - 96k - Nov 3, 2003 - Cached - Similar pages
[ More results from www.genomicglossaries.com ]

critical care forum | Full text | Acid–base status of ...
... and Figge and colleagues [7,8]. To identify acid–base changes that might be ... 4. Story
D, Poustie S, Bellomo R: Quantitative physical chemistry analysis of acid ...
ccforum.com/content/7/4/R60 - 79k - Cached - Similar pages

Biotech Capital Ltd
... to jump directly to glossary terms beginning ... genomics, proteomics, drug screening
and medicinal chemistry. ... resulting from minute, single-base changes in the ...
www.biotechcapital.com.au/glossary.asp - 42k - Nov 3, 2003 - Cached - Similar pages

Bioinformatics Glossary
Bioinformatics Glossary. ... of computer-based drug design, medicinal chemistry and pharmacology. ... that
includes genetic (point or single base) changes, or larger ...
www.bscbioinformatics.com/Stu/Glo/glossary.html - 101k - Cached - Similar pages

Glossary
... Path: Home / Glossary. ... of computer-based drug design, medicinal chemistry and pharmacology ... genome
that includes genetic (point or single base) changes, or larger ...
www.bscbioinformatics.com/Fac/Tools/glossary.html - 101k - Cached - Similar pages

eMJA: Clinical pharmacology
... alterations to gene structure are single-base changes in the ... Glossary. ... Combinatorial
chemistry: Simultaneous synthesis of chemical compounds with multiple ...
www.mja.com.au/public/issues/176_01_070102/ she10554_fm.html - 15k - Nov 3, 2003 - Cached - Similar pages

[PDF] Clinical pharmacology
File Format: PDF/Adobe Acrobat - View as HTML
... to gene structure are single-base changes in the ... t Clinical pharmacology Glossary
Microarray chips ... Combinatorial chemistry: Simultaneous synthesis of chemical ...
www.mja.com.au/public/issues/176_01_070102/ she10554_fm.pdf - Similar pages

DNA
... C. Previous knowledge about chemistry of DNA. ... 1. Ability to mutate is requirement
for genetic material; base changes during replication are one way mutations ...
arnica.csustan.edu/biol1010/dna/dna.htm - 11k - Cached - Similar pages

UPCI TaqMan Facility
... is a relatively new combination of instrumentation and chemistry which allows ... the
TaqMan technique and its ability to discriminate single base changes in DNA ...
www.upci.upmc.edu/internet/research/taqmanFac.html - 19k - Cached - Similar pages

Mike :)
Something went wrong...
+1
24 mins

base as in bases forming base pairs

... not 'basic' or fundamental.
Peer comment(s):
agree DGK T-I
3 hrs
Something went wrong...
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