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intent-to-treat analysis

German translation: Auswertungsverfahren von klinischen Studien

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:intent-to-treat analysis
German translation:Auswertungsverfahren von klinischen Studien
Entered by: Maya Jurt
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- Include in personal glossary

21:00 Oct 27, 2000
English to German translations [PRO]
Medical - Mathematics & Statistics
English term or phrase: intent-to-treat analysis
in preparation for a clinical trial
Dirgis
United States
Local time: 19:24
more on intent to treat
Explanation:
This analysis does not, as its name would seem to indicate, pertain to the analysis a treatment plan or of an intended treatment. Rather, it refers to the statistical evaluation of data from clinical studies. See below:

intent-to-treat analysis: (engl.) Auswertungsverfahren von klinischen Studien, bei dem alle Patienten berücksichtigt werden. Begleitmedikationen oder Noncompliance führen nicht zu einem Ausschluß von der Auswertung. Die Effektivität einer Therapie unter realistischen Bedingungen soll bewertet werden.
http://www.aidshilfe.de/

The method of including all randomized subject's data into an analysis, regardless of compliance, is know as an "intent-to-treat analysis". While it may seem logical to exclude non-compliant subjects, restricting the analysis to compliant subjects can lead to biased results. If non-compliance is in any way related to outcome, restricting analysis could misrepresent differences between treatment groups. If subjects are non-compliant due to failure to improve, side effects, or any other factor that is related to outcome, the result may be misrepresented. Although the intent-to-treat analysis is used by most clinical trials conducted today, there are times when it may not be appropriate. In situations involving treatment crossovers which were not planned, systematic, or incorporated into the study design, an intent-to-treat analysis may be inappropriate. The choice of statistical procedure depends upon the nature of the outcome variable. Regardless of the analytic approach, the better the subject compliance to the study procedures, the more reliable and valid the data will be.
http://www.researchpractice.com/cumulative/cum_jf98_1.shtml
Selected response from:

Ulrike Lieder
Local time: 16:24
Grading comment
Thanks Uel,
that sounds as if there is no short translation for it.
Regards
Sigrid

4 KudoZ points were awarded for this answer

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Summary of answers provided
namore on intent to treatUlrike Lieder
naAnalyse des Behandlungsplanes oder der beabsichtigten Behandlung
Elisabeth Moser


  

Answers


3 hrs
Analyse des Behandlungsplanes oder der beabsichtigten Behandlung


Explanation:
intent=jur. wahre Bedeutung, Sinn (Gesetz), Absicht--auch: Ziel, Zweck, Plan
you have to see what fits best your context. Contrary of the answer you got
on your first questionm, I would translate it.
Good luck,
Lis


    Muret-Sanders
Elisabeth Moser
United States
Local time: 19:24
Native speaker of: Native in GermanGerman
PRO pts in category: 4

Peer comments on this answer (and responses from the answerer)
Ulrike Lieder
Login to enter a peer comment (or grade)

14 hrs
more on intent to treat


Explanation:
This analysis does not, as its name would seem to indicate, pertain to the analysis a treatment plan or of an intended treatment. Rather, it refers to the statistical evaluation of data from clinical studies. See below:

intent-to-treat analysis: (engl.) Auswertungsverfahren von klinischen Studien, bei dem alle Patienten berücksichtigt werden. Begleitmedikationen oder Noncompliance führen nicht zu einem Ausschluß von der Auswertung. Die Effektivität einer Therapie unter realistischen Bedingungen soll bewertet werden.
http://www.aidshilfe.de/

The method of including all randomized subject's data into an analysis, regardless of compliance, is know as an "intent-to-treat analysis". While it may seem logical to exclude non-compliant subjects, restricting the analysis to compliant subjects can lead to biased results. If non-compliance is in any way related to outcome, restricting analysis could misrepresent differences between treatment groups. If subjects are non-compliant due to failure to improve, side effects, or any other factor that is related to outcome, the result may be misrepresented. Although the intent-to-treat analysis is used by most clinical trials conducted today, there are times when it may not be appropriate. In situations involving treatment crossovers which were not planned, systematic, or incorporated into the study design, an intent-to-treat analysis may be inappropriate. The choice of statistical procedure depends upon the nature of the outcome variable. Regardless of the analytic approach, the better the subject compliance to the study procedures, the more reliable and valid the data will be.
http://www.researchpractice.com/cumulative/cum_jf98_1.shtml


Ulrike Lieder
Local time: 16:24
Native speaker of: German
PRO pts in category: 4
Grading comment
Thanks Uel,
that sounds as if there is no short translation for it.
Regards
Sigrid
Login to enter a peer comment (or grade)




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Changes made by editors
Oct 7, 2007 - Changes made by Steffen Walter:
Field (specific)(none) » Mathematics & Statistics


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