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11:11 May 31, 2002
English to Greek translations [Non-PRO] Medical
English term or phrase:phrase
In some latently infected B cells such as Ragi, LMP1 expression can be increased by treatment with activators of PLC, which increase early lytic cycle promotor activity. The promotor for full-length LMP1 expression in lytic infection has not been characterized. In late lytic infection, a promotor in the third lmp1 exon transcribes the part of the lmp1 ORF that encodes the last 2 transmemberane domains and the entire lmp1 cytoplasmic domain . this smaller integral membrane protein , referred to as D1LMP1 , localizes to cytoplasmic membranes and doesn’t have the transforming or cell activating properties of LMP1 and doesn’t associate with vimentine or other cytoskeletal elements. The detection of LMP1 but not D1LMP1 in preparations of purified virus and newly infected cells indicates that LMP1 maybe incorporated into virions . this raises the possibility that virion – associated LMP1 could have an effect on the growth of newly infected cells.
The expression of LMOP1 in 3 lineages of transgenic mice under control of the immunoglobulin heavy chain promotor and enhancer result in low – level expression in normal lymphoid tissue and an increase in B-cell hyperpasia and lymphomas . The incidence of lymphoma increased significantly mice over 18 months of age. The lymphomas are monoclonal or oligoclonal by 1gH rearrangement , and LMP1 is expressed at LCL levels in the lymphomas . These data indicate that LMP1 alone can be oncogenic in B-lymphocytes in vivo. B cells or transgenic mice expressing LMP1 under the control of immunoglobulin promotor/ enhancer – displayed enhanced expression of activation of antigens , spontaneously proliferated and produced antibody . LMP1 expression in transgenic mice in CD 40- deficient or normal backgrounds mimics CD40 signals to induce extra follicular B –cell differentiation and blocks germinal center formation.
LMP2 A and –2B
The coloning and sequencing of cDNAs to 2.3 – and 2.0-kb cytoplasmic polyoadenylated RNAs from latently infected cell provided the first evidence for 2 integral membrane proteins that were designated LMP2A and –2B, or TP1 and –2 . the first exons of LMP2A and –2B are the the only unique exons ; all other exons are shared by LMP2A and –2B . the first LMP2A exons is predicted to encode for a 119-amonoacid hydrophilic amino-terminal cytoplasmic domain. The first LMP2B exon is short and LACKS a methionine codon. Translation of LMP2B initiates at a metionine codon at the beginning of the common second exon, before the first transmembrane sequence. The remaining LMP2A and –2B exons are predicated to encode 12 hydrophobic integral memberane sequence separated by short reverse turns and a 27-amino-acid hydrophilic carboxy 1 – terminal dominion. Nonspecific antisera generated against LMP2 fusion proteins localize LMP2A to a patch in the plasma membrane of latently infected B lymphocytes where it co-localizes with LMP1.
LMPA2 localizes to the same site in the plasma membrane of B – lymphoma