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English to Italian translations [PRO] Science - Biology (-tech,-chem,micro-) / dolore neuropatico
English term or phrase:scrambling
Un progetto studia il ruolo della proteina anoctamina-6 nel dolore neuropatico:
Researchers utilised a novel genetically encoded indicator called Cl-Sensor and having a genetic mutation that increases sensitivity to Cl-. Two mouse lines were created that expressed this Cl- sensor to functionally characterise intra–cellular Cl- changes in nerve cells using ratiometric tools. Anoctamin-6's role as a Cl- channel was confirmed in a heterologous system transiently transfected with anoctamin-6 cDNA.
Fluourescent-activated cell sorting, site-directed mutagenesis and time-lapse microscopy were used to reveal its role in calcium-dependent ***scrambling*** of phospholipids such as phosphatidylserine (PS).