Italian translation: aumento di/delle dimensioni delle isole di Langerhans
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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:
enlargement of the islets of Langerhans
aumento di/delle dimensioni delle isole di Langerhans
English to Italian translations [PRO] Medical - Medical: Pharmaceuticals / Farmaco antidiabetico
English term or phrase:enlargement of the islets of Langerhans
5.3 Preclinical safety data
In repeated dose toxicity studies with oral administration of high doses of glibenclamide, effects on pancreatic beta-cells were observed (** enlargement of the islets of Langerhans ** with irregularly configured islets and reduction in pancreatic β-cell granulation in rats at doses of ≥ 30 mg/kg/d, beta-cell exhaustion as indicated by depletion of insulin-containing granules in rabbits at doses of > 100 mg/kg/d)."