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Explanation: In roman letters : genki?/doh shita no?/ nani?
My understanding is "what's up " is really a broad concept which can encompass all the meanings of the following phrases depending on the situation: "What's new" "what happened""what""what's the matter" "have you been doing ok" or sometimes maybe "how are you". Especially when someone starts a conversation, the other person has a choice of what to talk about.
If you meant to say "what's up" to start a conversation, you can say 元気"gennki?" which literally means "are you doing ok" , or if you are a guy おっす"ossu！" which is a slang for hi. These are the two words that will give the other person a choice of whether to just say a word and go away or start chatting.
If you want to say "what's up" to someone who came to you for a chat or when you receive a phone call, you can say どうしたの"doh shita no" which literally means "what is it""what's the matter""what" or 何"nani" which is "what"
These are all used in casual conversation between friends.
mimichan Local time: 23:54 Native speaker of: Japanese PRO pts in pair: 16