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04:04 Jan 9, 2002
English to Malay translations [Non-PRO] Science - Textiles / Clothing / Fashion / textiles
English term or phrase:TCR
Generation of TCR Diversity
Overall, the amouint of diversity in the TCR is comparable with that of the immunoglobulin genes.
The TCR has a different requirement for diversity than the immunoglobulin. Immunoglobulins have to bind to a wide variety of ligands. The ligand for a T-cell receptor is always an MHC molecule. Consequently, the TCRs have a relatively invariant shape and most of the diversity is focused on the bound antigenic peptide occupying the center of the surface in contact with the receptor.
The TCR must recognize a very large number of different processed antigens in association with a limited number of self MHC molecules.
TCRs have CDR1, CDR2 and CDR3. CDR3 forms the center of the antigen binding site in the TCR. CDR1 and CDR2 forms the the periphery of the antigen binding site in the TCR.
CDR1 and CDR2 are encoded within the germ line V gene segments for both a and b chains. Since the TCR does not undergo somatic hypermutation, there is a limited amount of diversity in the CDR1 and CDR2 regions of the TCR.
Most of the diversity in TCR is generated during rearrangement and consequently is focused on the CDR3 region. Consequently, the center of the TCR will be highly variable while the periphery is subject to little variation. In this way, the most variable part of the TCR corresponds to the most variable part of its ligand (the bound foreign peptide in the MHC antigen binding site).
The limited number of V region gene segments may generate the diversity needed for MHC recognition, whereas the enormous diversity generated at the junctional regions facilitates recognition of antigen.
Somatic hypermutation does not occur in TCR genes, so that the variability of CDR1 and CDR2 is limited to that of the germline V region gene segment. One reason that T cells do not undergo somatic hypermutation is that it could be disastrous if a T cell receptor was to arise in the periphery that reacted with a self protein. Remember that T cells spend a long time undergoing thymic education just to avoid these self-reactive problems!. This is not so critical with B cells which are going to require T cell help in most instances to produce antibodies. Additionally, somatic hypermutation might prevent the T cell recognizing self MHC.
Explanation: TCR = T Cell Receptor (BI)
Saya sering menterjemah bahan2 perubatan & farmaseutika dan pernah menyempurnakan penterjemahan tentang CD3, CD4 & CD8 dan reseptor sel T sebagai padanan bagi TCR telah diterima (maaf tak dapat menamakan klien saya)