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English to Polish translations [PRO] Science - Biology (-tech,-chem,micro-)
English term or phrase:conserved residues
The investigation of the extent to which CONSERVED RESIDUES are clustered in three-dimensional protein structures:
The most conserved positions in multiple sequence alignments are significantly more clustered than randomly selected sets of positions. The comparison to random subsets is not necessarily appropriate, however, because the signal could be the result of differences in the amino acid composition of sets of CONSERVED RESIDUES compared to random subsets.
In order to overcome these limits, we compare the degree of clustering of the conserved positions on the native structure and on alternative conformations generated by the de novo structure prediction method Rosetta. The CONSERVED RESIDUES are significantly more clustered in the native structure than in the alternative conformations, indicating that the clustering of CONSERVED RESIDUES in protein structures goes beyond that expected purely from sequence locality and composition effects.