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gatekeeper threonine residues

Polish translation: wartownicze reszty treoninowe/treoniny

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:gatekeeper threonine residues
Polish translation:wartownicze reszty treoninowe/treoniny
Entered by: EvaRoma
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16:43 Aug 24, 2010
English to Polish translations [PRO]
Medical - Medical (general)
English term or phrase: gatekeeper threonine residues
mutation is homologous to the resistance mutations of the gatekeeper threonine residues in BCR-ABL
EvaRoma
Local time: 14:25
wartownicze reszty treoninowe/treoniny
Explanation:
Odpowiedź grubo po czasie, ale wymaga chyba wyjaśnienia: to reszty treoninowe, które w białku zmutowanym są wymieniane na reszty izoleucynowe. To zmniejsza podatność białka BCR/ABL na drobnocząsteczkowe ligandy:
"The 'gatekeeper mutation' T315I is responsible for a general resistance to small molecules. It seems not only to decrease the affinity for kinase inhibitors, but to also confer additional features to the leukemogenic potential of BCR/ABL."
Selected response from:

Błażej Rychlik
Poland
Local time: 14:25
Grading comment
4 KudoZ points were awarded for this answer

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Summary of answers provided
5wartownicze reszty treoninowe/treoniny
Błażej Rychlik
Summary of reference entries provided
aminokwas l-treonina
geopiet

  

Answers


562 days   confidence: Answerer confidence 5/5
wartownicze reszty treoninowe/treoniny


Explanation:
Odpowiedź grubo po czasie, ale wymaga chyba wyjaśnienia: to reszty treoninowe, które w białku zmutowanym są wymieniane na reszty izoleucynowe. To zmniejsza podatność białka BCR/ABL na drobnocząsteczkowe ligandy:
"The 'gatekeeper mutation' T315I is responsible for a general resistance to small molecules. It seems not only to decrease the affinity for kinase inhibitors, but to also confer additional features to the leukemogenic potential of BCR/ABL."

Example sentence(s):
  • http://www.nature.com/leu/journal/v23/n9/full/leu200969a.html
Błażej Rychlik
Poland
Local time: 14:25
Specializes in field
Native speaker of: Polish
PRO pts in category: 335
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Reference comments


5 hrs
Reference: aminokwas l-treonina

Reference information:
Reference: aminokwas l-treonina


There are two most common types of glycoproteins: O- and N-glycoproteins.
In eukaryotes, the most prevalent type of O-linked glycosylation is the mucin-type glycosylation, where N-acetyl-D-galactosamine (GalNAc)
is linked in an a-anomeric configuration to the b-hydroxyl group of either a serine or a threonine residue of the polypeptide

http://www.dbc.wroc.pl/Content/2257/1-2_.pdf - page 83

=================

Pierwszą resztą cukrową przyłączoną do O-glikanu jest najcz궜ciej N-acetylo-D-galaktozamina, która podstawiana jest do
łańcucha bocznego reszty L-seryny lub L-treoniny

http://www.dbc.wroc.pl/Content/2257/1-2_.pdf - 89. strona

geopiet
Native speaker of: Native in PolishPolish
PRO pts in category: 320
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