differential stress resistance

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15:46 May 11, 2018
English to Polish translations [PRO]
Medical - Other
English term or phrase: differential stress resistance
Thus, metformin can promote both differential stress resistance and differential stress sensitization by both
reducing glucose levels and acting on PKA signaling as described in
Raffaghello et.al, PNAS. 2008

Dostałam przetłumaczony tekst dot. działania leku, który podobnie oddziałuje na organizm jak głodówka. Tekst ogólnie dotyczy leczenia nowotworów i skutków ubocznych chemioterapii. Nie jestem pewna, czy to pojęcie zostało właściwie przetłumaczone. Podobnie "differential stress sensitization".
Local time: 21:02

Summary of answers provided
2różnica w odporności na stres oksydacyjny między zdrowymi i nowotworymi komórkami
Frank Szmulowicz, Ph. D.



2 hrs   confidence: Answerer confidence 2/5Answerer confidence 2/5
różnica w odporności na stres oksydacyjny między zdrowymi i nowotworymi komórkami

Differential refers to a difference in response, here, to the oxidative stress, between normal and cancer cells.

Possibly, zróżnicowana odporność na stres oksydacyjny między zdrowymi i nowotworymi komórkami


Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

Here, we describe a differential stress resistance (DSR) method that focuses instead on protecting the organism but not cancer cells against chemotherapy

These studies describe a starvation-based DSR strategy to enhance the efficacy of chemotherapy and suggest that specific agents among those that promote oxidative stress and DNA damage have the potential to maximize the differential toxicity to normal and cancer cells.


As previously shown by Lee et al, circulating Insulin-like growth factor 1 (IGF-1)
is a key factor affected by fasting and its reduction is crucial for the establishment of Differential Stress Sensitization (DSS), a condition where cancer but not normal cell are sensitized, particularly in the presence of cytotoxic drugs(Lee et al. 2012).

HO-1 is known to confer protection against oxidative damage and apoptosis Chen et al. 2004), promote tumor progression (Hirai et al. 2007; Liu et al. 2011; Metz et al. 2010) and have immuno-modulatory roles that affect various T cell subpopulations including Tregs (Brusko et al. 2005; Xia et al. 2008).

Oxidative stress and the production of reactive oxygen species during
chemotherapy treatment can damage normal cells, and is implicated in the toxicity of doxorubicin(Conklin 2000).


Frank Szmulowicz, Ph. D.
United States
Local time: 15:02
Native speaker of: Native in EnglishEnglish, Native in PolishPolish
PRO pts in category: 834
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