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English to Portuguese translations [PRO] Medical - Medical (general)
English term or phrase:enriched population
The 50 mg dose is currently used in phase IIb/III trials in NSCLC patients progressing on erlotinib or gefitinib, as maximum EGFR inhibition is required in this last-line population enriched for the presence of resistance mutations.
The results of first-line treatment with EGFR TKIs compare favourably with historical controls. However, only prospective and controlled clinical trials can establish these treatments as a new standard. The objective of this trial is to assess whether a targeted treatment for a targeted population can be identified, providing maximum benefit to the enriched population, whilst sparing those patients who are not likely to benefit.