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15:28 Aug 3, 2006
English to Russian translations [PRO] Medical - Medical: Pharmaceuticals
English term or phrase:closed conformation
Imatinib appears to work by blocking the BCR-ABL in the closed conformation, and thus eliminating the possibility for ATP to bind (Branford, 2003). Unlike imatinib, dasatinib can bind to both the active and inactive conformations of BCR-ABL, thus increasing its possibility to inhibit the kinase activity.