17:14 May 1, 2008
Вот еще контекст, если поможет. Мне кажется здесь нужно знать (?), что имеено происходит при частичном агонизме.
The affinities for the 5-HT1A and 5-HT3 receptors are considered to be of clinical relevance and to be involved in the mechanism of action of ХХХХ. The antidepressant potential of ХХХХ has been demonstrated in vivo in the mouse forced swim and tail suspension models. In the rat, ХХХХ produced a larger increase in 5-HT levels than did the selective serotonin reuptake inhibitor (SSRI) citalopram both after acute treatment and after 3 days of treatment. Thus animal models predict that ХХХХ might have a greater therapeutic effect and a faster onset of effect than SSRIs. ХХХХ has also been shown to exert anxiolytic like effects in animal models (eg, rat conditioned fear) indicative of anxiolytic potential. The compound also increases acetylcholine, dopamine and norepinephrine (NE) levels in both the frontal cortex and ventral hippocampus suggesting a precognitive action and effects on attention and motivation. Lu AA21004 has also been shown to be efficacious in models of neuropathic pain. It is proposed that the action of ХХХХ at 5-HTT, 5-HT3, and 5-HT1A receptors produces this novel in vivo profile | 
peer agreement (net): +4
