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English to Russian translations [PRO] Medical - Medical (general)
English term or phrase:proto-oncogene LIM domain only 2 (LMO2)
Most importantly, insertional mutagenesis occurred in 3 patients with SCID-X1; γc gene transfer into CD34+ cells resulted in clonal T cell proliferation that became clinically overt after 3 years, leading to the death of 1 patient; it was controlled by chemotherapy in the 2 remaining patients. These serious complications clearly
resulted from retroviral integration leading to the aberrant expression of the proto-oncogene LIM domain only 2 (LMO2) in the first 2 observed cases