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09:30 Apr 5, 2008
English to Russian translations [PRO] Medical - Medical (general)
English term or phrase:sleep latency
The efficacy of ramelteon has been demonstrated in subjects 18 years of age with chronic primary insomnia over the short-term (1- to 5-weeks) duration. Objectively assessed using Polysomnography (PSG) and by patient reported outcome (post-sleep questionnaires [PSQ] and/or paper sleep diaries [SD]-subjective), it was demonstrated that ramelteon significantly reduces sleep latency.
Four placebo controlled studies were conducted to investigate sleep latency improvement.
The mean reduction of sleep latency compared with placebo measured by patient reported outcome (subjective) was up to 13 minutes and 19 minutes when evaluated by SD or PSQ, respectively. The mean sleep latency reduction when measured using PSG (objective) was up to approximately 16 minutes. Table 1 shows the individual study results for the reduction of sleep latency with ramelteon as compared to placebo.