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16:32 Feb 12, 2009
English to Russian translations [PRO] Medical - Medical (general)
English term or phrase:murine monoclonal antibody
Humanised antibodies are produced by grafting murine amino acid domains into human antibodies. This results in a molecule of approximately 95% human origin. However it has been shown in several studies that humanised antibodies bind antigen much more weakly than the parent murine monoclonal antibody, with reported decreases in affinity of up to several hundredfold