synergy/antagonism volumes

Russian translation: объемы областей синергизма/антагонизма (на трехмерном графике)

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:synergy/antagonism volumes
Russian translation:объемы областей синергизма/антагонизма (на трехмерном графике)
Entered by: Wolfskin
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08:43 Jun 27, 2018
English to Russian translations [PRO]
Law/Patents - Medical (general) / Комбинированное лекарственное средство
English term or phrase: synergy/antagonism volumes
The volumes of synergy or antagonism can be determined and graphically depicted in three dimensions and represent the relative quantity of synergism or antagonism per change in the two drug concentrations.
Synergy and antagonism volumes are based on the Bliss independence model, which assumes that both compounds act independently on different targets.
A set of predicted fractional responses faAB under the Bliss independence model is calculated as faAB =faA +faB - faA • faB with faA and faB representing the fraction of possible responses, e.g. % inhibition, of compounds A and B at amounts dA and dB, respectively, and describes the % inhibition of a combination of compounds A and B at amount (dA+dB).
If faAB > faA + faB - faA • faB then we have Bliss synergy; if faAB < faA+ faB - faA • faB then we have Bliss antagonism.
The 95% synergy/antagonism volumes are the summation of the differences between the observed inhibition and the 95% confidence limit on the prediction of faAB under the Bliss independence model.

Вот выдержка из публикации:
Figure ​Figure22 shows a representative result of this drug-drug combination analysis obtained with BVDV. As can be seen in the 95% confidence interval difference plot (Fig. ​(Fig.2A)2A) and contour plot (Fig. ​(Fig.2B),2B), there was a synergy of antiviral effects between the two drugs. According to the guidelines found in the MacSynergy II user's manual (31), the size of the synergy volume [86 IU(μg)/ml2%], derived from 95% confidence interval differential plots as described herein, indicates that this effect may be important in vivo. From an analysis of five independent experiments, we determined that this synergy volume was 66 ± 25 IU(μg)/ml2% (mean ± standard deviation). A clear antagonism of antiviral effects [antagonism volume = −690 IU(μg)/ml2%] between the drugs was also observed; however, this effect was seen only when high concentrations of RBV were employed. This antagonism volume averaged −940 ± 220 IU(μg)/ml2% in five repeat experiments.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC161860/

Я правильно, что это все же Объем?

Спасибо!
Wolfskin
Local time: 03:54
объемы областей синергизма/антагонизма (на трехмерном графике)
Explanation:
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.101...
The volumes of synergistic
or antagonistic regions are equal to the relative quantity of synergy or antagonism
produced per change in the two drug concentrations.
Selected response from:

hawkwind
Russian Federation
Local time: 10:54
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
3объемы областей синергизма/антагонизма (на трехмерном графике)
hawkwind


  

Answers


3 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
объемы областей синергизма/антагонизма (на трехмерном графике)


Explanation:
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.101...
The volumes of synergistic
or antagonistic regions are equal to the relative quantity of synergy or antagonism
produced per change in the two drug concentrations.

hawkwind
Russian Federation
Local time: 10:54
Works in field
Native speaker of: Native in RussianRussian
PRO pts in category: 260
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