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14:52 Feb 2, 2018
English to Russian translations [PRO] Medical - Medical: Pharmaceuticals
English term or phrase:intact drug
In bile from bile duct cannulated rats, a number of hydroxylated sunitinib and M1 and their sulfate and glucuronide conjugates were identified (SU011248-PDM-070).
The proposed sunitinib metabolic pathways in rats are shown in Figure 3.
Metabolism in Monkeys
Sunitinib was extensively metabolized in monkeys.
However, after oral dosing of [14C]SU010398 (salt form) to male and female monkeys, only intact drug and SU012662 were found as the major drug related compounds in systemic circulation.
The sum of AUC of sunitinib and SU012662 in plasma accounted for 31%-42% of plasma radioactivity AUC (SU011248-PDM-054).
Small amounts of other metabolites were also identified in plasma, including M11 and M2F.