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16:38 Feb 3, 2018
English to Russian translations [PRO] Medical - Medical: Pharmaceuticals
English term or phrase:dentin pulp
Loss of body weight (29% to 38%) was observed in rats treated for 13 weeks at 5 mg/kg/day, with associated mean Day 28 AUC(0-24) of 6407 ng•h/mL (Table 184.108.40.206.F, Study 2001-0010).
Body weight decreases were the result of broken incisors, which were associated with degeneration and/or necrosis of dentin pulp in the affected animals.
A partial recovery of body weight occurred in the last week of the study after powdered food was supplied to the animals.
Deaths occurred within 4 weeks of treatment initiation in rats given 15 mg/kg/day, with associated mean Day 28 AUC(0-24) of 31613 ng•h/mL.
Clinical chemistry changes consisted of minimal to slight increases in ALT, AST, and bilirubin, and a moderate decrease in albumin and instances of proteinuria and hematuria, observed at 15 mg/kg/day following 13 weeks of treatment.
Hematological changes consisted of a reduction in neutrophils, and progressive, slight to moderate anemia observed at 5 mg/kg/day.