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05:40 Feb 5, 2018
English to Russian translations [PRO] Medical - Medical: Pharmaceuticals / Nonclinical Overview
English term or phrase:protein deposition within the mesangium
In a 9-month monkey study increased mesangial matrix in the kidney cortex was observed at 6 mg/kg/day (Table 188.8.131.52L, Study 2003-0386).
This reversible finding had been observed at 12 mg/kg/day in a previous, investigative 8-week oral toxicity study in cynomolgus monkeys with sunitinib (Table 184.108.40.206J, Study 1225-174).
The particular mechanism of the lesion is uncertain but may be due to protein deposition within the mesangium.