Russian translation: высокая фармакологическая активность
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06:11 Feb 6, 2018
English to Russian translations [PRO] Medical - Medical: Pharmaceuticals
English term or phrase:superpharmacological activity
At the same dose in a 14-day investigative rat study, reduction of acidophilic cells and presence of castration cells and necrosis of pituitary anterior lobe were observed, but regressed completely following a 2-week recovery period (Table 22.214.171.124B, Study 2000-0519).
Pituitary effects were not observed in the chronic monkey study (Table 126.96.36.199L, Study 2003-0386).
As sunitinib is a potent multi-targeted receptor tyrosine kinase inhibitor, there is the potential that the vascular changes in the adrenal may be related to superpharmacological activity in the region.
Based on a single literature report, hemorrhage was not identified in the adrenal glands or other tissues in monkeys given bevacizumab for up to 13 weeks.
The lack of adrenal findings in that report and the presence of hemorrhage in sunitinib-treated monkeys may reflect a difference in potencies or distribution of the therapeutic agents, or may be due to effects of sunitinib on other receptor kinases.