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superpharmacological activity

Russian translation: высокая фармакологическая активность

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06:11 Feb 6, 2018
English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: superpharmacological activity
At the same dose in a 14-day investigative rat study, reduction of acidophilic cells and presence of castration cells and necrosis of pituitary anterior lobe were observed, but regressed completely following a 2-week recovery period (Table 2.6.7.7B, Study 2000-0519).

Pituitary effects were not observed in the chronic monkey study (Table 2.6.7.7L, Study 2003-0386).

As sunitinib is a potent multi-targeted receptor tyrosine kinase inhibitor, there is the potential that the vascular changes in the adrenal may be related to superpharmacological activity in the region.

Based on a single literature report, hemorrhage was not identified in the adrenal glands or other tissues in monkeys given bevacizumab for up to 13 weeks.

The lack of adrenal findings in that report and the presence of hemorrhage in sunitinib-treated monkeys may reflect a difference in potencies or distribution of the therapeutic agents, or may be due to effects of sunitinib on other receptor kinases.
Maxim Polukhin
Local time: 21:27
Russian translation:высокая фармакологическая активность
Explanation:
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Note added at 56 мин (2018-02-06 07:08:31 GMT)
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для усиления можно добавить еще "высокая избирательная фармакологическая активность"
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Doctor Alex
Local time: 21:27
Grading comment
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Summary of answers provided
4высокая фармакологическая активность
Doctor Alex


  

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55 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
высокая фармакологическая активность


Explanation:
.

--------------------------------------------------
Note added at 56 мин (2018-02-06 07:08:31 GMT)
--------------------------------------------------

для усиления можно добавить еще "высокая избирательная фармакологическая активность"

Doctor Alex
Local time: 21:27
Specializes in field
Native speaker of: Native in RussianRussian, Native in UkrainianUkrainian
PRO pts in category: 651
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