Russian translation: в месте соединения с пилорическим отделом желудка
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06:13 Feb 6, 2018
English to Russian translations [PRO] Medical - Medical: Pharmaceuticals
English term or phrase:pyloric junction
Gastroduodenal or duodenal carcinoma, accompanied by hyperplasia of Brunner’s glands or gastric mucosa, was observed in hemizygous rasH2 transgenic mice in studies of 1- and 6-month duration or Sprague-Dawley rats in a 2-year carcinogenicity assessment.
In the 1-month range-finding study, carcinoma of the Brunner’s gland, located in the duodenal submucosa at the pyloric junction, was observed in emizygous rasH2 transgenic mice at 200 mg/kg/day (Table 22.214.171.124A, Study 2005-0088).
The carcinoma was observed in 2 female mice, one of which was found dead on Day 26 and the other was 1 of 2 main study animals that survived to term.
Hyperplasia of Brunner’s glands and gastric mucosal hyperplasia were also observed at 200 mg/kg/day.
Systemic exposure at 200 mg/kg/day was not defined due to excessive mortality in the TK satellite groups (wild type and hemizygous).