Russian translation: применение (введение) препарата было прекращено досрочно в день 15 беременности
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09:24 Feb 6, 2018
English to Russian translations [PRO] Medical - Medical: Pharmaceuticals
English term or phrase:was terminated early on Gestation Day 15
Presumed pregnant female rabbits were given 0.5 to 20 mg/kg/day on Gestation Days 7 through 21, with mean Day 14 AUC(0-24) values ranging from 288 to 5140 ng•h/mL (Table 18.104.22.168.B, Study 2002-0613).
Due to severe toxicity and escalating body weight loss, the 20 mg/kg/day treatment group *was terminated early on Gestation Day 15*.
Reductions in gravid uterine weights, increased number of resorptions, and a decreased number of viable fetuses (including complete litter loss in 4 of 6 does) were observed at 5 mg/kg/day, with associated mean Day 12 AUC(0-24) of 5140 ng•h/mL.