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21:02 Feb 26, 2018
English to Russian translations [PRO] Medical - Medical: Pharmaceuticals
English term or phrase:Landmark Analysis
Landmark Analysis for Key Secondary Composite Efficacy Endpoint
The reduction in the risk of the hard MACE endpoint was primarily driven by a clinically significant 27% reduction in MI (HR:
0.73; 95% CI: 0.65 to 0.82; nominal p ≤ 0.01) and a 21% reduction in stroke (HR: 0.79; 95% CI: 0.66 to 0.95; nominal p = 0.01).
In an exploratory analysis, the relative risk reduction for fatal and nonfatal MI or stroke was greater over time—the benefit was 19% (HR 0.81; 95% CI: 0.70 to 0.93) in the first year and 33% (HR 0.67; 95% CI: 0.59 to 0.77) beyond the first year.