Claudin (CLDN)18.2-positive

Russian translation: [опухолями,] экспрессирующими белок Claudin (CLDN)18.2

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17:36 Mar 13, 2018
English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: Claudin (CLDN)18.2-positive
ХХХХ is a global, multi-center, double-blind, randomized study to assess the efficacy of investigational product ХХХХ plus ХХХХ compared with placebo plus ХХХХ as first-line treatment in patients with Claudin (CLDN)18.2-positive, human epidermal growth factor receptor 2 (HER2)-negative tumors.
Anastasia Serdyukova
Russian Federation
Local time: 04:36
Russian translation:[опухолями,] экспрессирующими белок Claudin (CLDN)18.2
Explanation:
Abstract
Background
Claudin(CLDN)18.2 is a stomach specific tight junction protein. The chimeric monoclonal anti-CLDN18.2 antibody IMAB362 potently activates complement and antibody dependent cellular cytotoxicity. FAST investigated CLDN18.2 tumor expression and therapy with IMAB362 in combination with first line chemotherapy in pts with advanced gastric and GEJ cancer.

Methods
Pts with advanced gastric and GEJ cancer were centrally evaluated for CLDN18.2 by immunohistochemistry (CLAUDETECT18.2® Kit). CLDN18.2 expression of ≥ 2+ in ≥ 40% tumor cells was defined positive. Eligible pts required CLDN18.2+ tumors, an ECOG PS of 0–1, and no medical need for trastuzumab treatment. Pts were randomized 1:1 to first line EOX (epirubicin 50 mg/m2, oxaliplatin 130 mg/m2 d1, and capecitabine 625 mg/m2 bid, d1–21; qd22) with or without IMAB362 (loading dose 800 mg/m2, then 600 mg/m2 d1, qd21). An exploratory 3rd arm was added after arms 1 and 2 had enrolled ∼80% of pts to test a higher dose of IMAB362 (1000 mg/m2) plus EOX. The primary study endpoint was PFS (arm1 v 2, 70% power, HR 0.72, 1-sided p = 0.1).

http://oncologypro.esmo.org/Meeting-Resources/ESMO-Asia-2016...

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Note added at 14 mins (2018-03-13 17:50:27 GMT)
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The specific staining was evaluated by two independent raters and analysis of staining intensities (range 0-3+) and relative proportions of tumor cells were performed. One hundred three (59.2%) samples of primary PDAC were found positive. The vast majority of positive samples were characterized to highly express CLDN18.2: 54.6% (N = 95) with staining intensities of ≥ 2+. NEN were positive in 20% of cases (all ≥ 2+). Metastases of pancreatic neoplasms were also frequently found positive with comparable high rates (69.4% of lymph node and 65.7% of liver metastases).

https://www.ncbi.nlm.nih.gov/pubmed/23900716

https://www.findit.com/ojpyfkwdtxjiqgl/RightNow/taking-claud...

Уровень экспрессии уже будет заложен в протоколе.

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Note added at 16 mins (2018-03-13 17:52:56 GMT)
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В перевод можно вписать так, например: ... у пациентов с опухолями, экспрессирующими белок Claudin (CLDN)18.2 и не экспрессирующими рецептор 2 эпидермального фактора роста человека (HER2)

--------------------------------------------------
Note added at 19 mins (2018-03-13 17:55:27 GMT)
--------------------------------------------------

Хотя вот его уже пишут и как "клаудин", поэтому можно и транслитерировать:

https://www.google.com.ua/search?client=opera&q=экспрессия C...

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Note added at 21 mins (2018-03-13 17:58:10 GMT)
--------------------------------------------------

клаудин (CLDN) 18.2:

https://www.google.com.ua/search?client=opera&q=клаудин 18.2...

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Note added at 27 mins (2018-03-13 18:04:10 GMT)
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Это если русским языком. Пишут, конечно, и "[название молекулы/структуры]-позитивных" и "[название молекулы/структуры]-негативных".

--------------------------------------------------
Note added at 35 mins (2018-03-13 18:11:21 GMT)
--------------------------------------------------

https://www.google.com.ua/search?client=opera&q=HER2-позитив...

https://www.google.com.ua/search?client=opera&q=HER2-позитив...

или еще пишут "позитивным по [название молекулы/структуры]" и "негативным по [название молекулы/структуры]"

https://www.google.com.ua/search?client=opera&hs=jSW&ei=pROo...

https://www.google.com.ua/search?client=opera&hs=anB&ei=rxOo...

или "позитивным статусом экспрессии [название молекулы/структуры]" и "негативным статусом экспрессии [название молекулы/структуры]"

--------------------------------------------------
Note added at 38 mins (2018-03-13 18:14:46 GMT)
--------------------------------------------------

"с экспрессией [название молекулы/структуры], без экспрессии [название молекулы/структуры]"

Все что можно уже перечислил, хотя суть та же :-)
Selected response from:

Evgeni Kushch
Ukraine
Local time: 04:36
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +1[опухолями,] экспрессирующими белок Claudin (CLDN)18.2
Evgeni Kushch


  

Answers


9 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
claudin (cldn)18.2-positive
[опухолями,] экспрессирующими белок Claudin (CLDN)18.2


Explanation:
Abstract
Background
Claudin(CLDN)18.2 is a stomach specific tight junction protein. The chimeric monoclonal anti-CLDN18.2 antibody IMAB362 potently activates complement and antibody dependent cellular cytotoxicity. FAST investigated CLDN18.2 tumor expression and therapy with IMAB362 in combination with first line chemotherapy in pts with advanced gastric and GEJ cancer.

Methods
Pts with advanced gastric and GEJ cancer were centrally evaluated for CLDN18.2 by immunohistochemistry (CLAUDETECT18.2® Kit). CLDN18.2 expression of ≥ 2+ in ≥ 40% tumor cells was defined positive. Eligible pts required CLDN18.2+ tumors, an ECOG PS of 0–1, and no medical need for trastuzumab treatment. Pts were randomized 1:1 to first line EOX (epirubicin 50 mg/m2, oxaliplatin 130 mg/m2 d1, and capecitabine 625 mg/m2 bid, d1–21; qd22) with or without IMAB362 (loading dose 800 mg/m2, then 600 mg/m2 d1, qd21). An exploratory 3rd arm was added after arms 1 and 2 had enrolled ∼80% of pts to test a higher dose of IMAB362 (1000 mg/m2) plus EOX. The primary study endpoint was PFS (arm1 v 2, 70% power, HR 0.72, 1-sided p = 0.1).

http://oncologypro.esmo.org/Meeting-Resources/ESMO-Asia-2016...

--------------------------------------------------
Note added at 14 mins (2018-03-13 17:50:27 GMT)
--------------------------------------------------

The specific staining was evaluated by two independent raters and analysis of staining intensities (range 0-3+) and relative proportions of tumor cells were performed. One hundred three (59.2%) samples of primary PDAC were found positive. The vast majority of positive samples were characterized to highly express CLDN18.2: 54.6% (N = 95) with staining intensities of ≥ 2+. NEN were positive in 20% of cases (all ≥ 2+). Metastases of pancreatic neoplasms were also frequently found positive with comparable high rates (69.4% of lymph node and 65.7% of liver metastases).

https://www.ncbi.nlm.nih.gov/pubmed/23900716

https://www.findit.com/ojpyfkwdtxjiqgl/RightNow/taking-claud...

Уровень экспрессии уже будет заложен в протоколе.

--------------------------------------------------
Note added at 16 mins (2018-03-13 17:52:56 GMT)
--------------------------------------------------

В перевод можно вписать так, например: ... у пациентов с опухолями, экспрессирующими белок Claudin (CLDN)18.2 и не экспрессирующими рецептор 2 эпидермального фактора роста человека (HER2)

--------------------------------------------------
Note added at 19 mins (2018-03-13 17:55:27 GMT)
--------------------------------------------------

Хотя вот его уже пишут и как "клаудин", поэтому можно и транслитерировать:

https://www.google.com.ua/search?client=opera&q=экспрессия C...

--------------------------------------------------
Note added at 21 mins (2018-03-13 17:58:10 GMT)
--------------------------------------------------

клаудин (CLDN) 18.2:

https://www.google.com.ua/search?client=opera&q=клаудин 18.2...

--------------------------------------------------
Note added at 27 mins (2018-03-13 18:04:10 GMT)
--------------------------------------------------

Это если русским языком. Пишут, конечно, и "[название молекулы/структуры]-позитивных" и "[название молекулы/структуры]-негативных".

--------------------------------------------------
Note added at 35 mins (2018-03-13 18:11:21 GMT)
--------------------------------------------------

https://www.google.com.ua/search?client=opera&q=HER2-позитив...

https://www.google.com.ua/search?client=opera&q=HER2-позитив...

или еще пишут "позитивным по [название молекулы/структуры]" и "негативным по [название молекулы/структуры]"

https://www.google.com.ua/search?client=opera&hs=jSW&ei=pROo...

https://www.google.com.ua/search?client=opera&hs=anB&ei=rxOo...

или "позитивным статусом экспрессии [название молекулы/структуры]" и "негативным статусом экспрессии [название молекулы/структуры]"

--------------------------------------------------
Note added at 38 mins (2018-03-13 18:14:46 GMT)
--------------------------------------------------

"с экспрессией [название молекулы/структуры], без экспрессии [название молекулы/структуры]"

Все что можно уже перечислил, хотя суть та же :-)

Evgeni Kushch
Ukraine
Local time: 04:36
Specializes in field
Native speaker of: Native in RussianRussian, Native in UkrainianUkrainian
PRO pts in category: 832
2 corroborated select projects
in this pair and field What is ProZ.com Project History(SM)?

Peer comments on this answer (and responses from the answerer)
agree  Natalie: Что-то слишком много букафф :-) А должно быть: "...с клаудин-позитивными, HER2-негативными опухолями"
1 hr
  -> Спасибо, Наталья! Там же еще расшифровки, пытался их впихнуть.
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