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01:20 Jul 5, 2007
English to Spanish translations [PRO] Medical - Biology (-tech,-chem,micro-)
English term or phrase:selectivity over
Estoy revisando la traducción de dos patentes del área farmacéutica y me topé con la siguiente duda.
"In particular, certain compounds of Formula I wherein OR2 is OH were found to be at least 50-fold more selective for AKT versus protein kinase A (PKA). For example, at least 100-fold, and as a further example, at least 150-fold more selective for AKT versus PKA. **Selectivity over** PKA is desirable, since PKA is involved in many cellular processes important for the normal function and physiology of many cell types. Additionally, inhibition of PKA is not believed to contribute to the anti-proliferative and pro-apoptotic effects of AKT inhibition. Thus, inhibition of PKA could lead to adverse events not associated with AKT inhibition without contributing to the disease modifying benefits of AKT inhibition."
¡Hola Yvonne! Also not my field, but it looks to me that 'selectivity over PKA' is equivalent to 'greater/increased/higher selectivity *for* AKT' -- if this helps in English. The Formula I compounds were more selective for AKT *than* for PKA.
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56 mins confidence: peer agreement (net): -1
Explanation: **Selectivity over** PKA is desirable, since PKA is involved in many cellular processes important for the normal function and physiology of many cell types.
Es deseable la selectividad para PKA, debido a que la PKA interviene en muchos procesos celulares propios del normal funcionamiento y fisiología de muchos tipos de células.
Sara Brown Argentina Local time: 11:58 Specializes in field Native speaker of: English, Spanish PRO pts in category: 39