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tophus response, target tophus ETC

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19:38 Aug 31, 2014
English to Spanish translations [PRO]
Medical - Medical: Pharmaceuticals / treatment of gout
English term or phrase: tophus response, target tophus ETC
I have written in capital letters where I need expertise suggestions. Thanks!

Efficacy Assessments of XYZ medication:

FIRST QUESTION:

Proportion of subjects with a BEST TOPHUS RESPONSE on at least 1 TARGET TOPHUS of complete or partial resolution by Month 12

SECOND QUESTION:

Objective:

To investigate by a population analysis approach the influence of intrinsic factors (age, race, sex, body weight, renal function, concomitant medication use) ON ORAL CLEARANCE of "medication".
Taous Sawyer
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Summary of reference entries provided
respuesta al tofo, objetivos del tofo, etc.
spielenschach1
references to check
Joseph Tein
EU Clinical Trial register
LauraCavatorta

  

Reference comments


2 hrs
Reference: respuesta al tofo, objetivos del tofo, etc.

Reference information:
tophus - definition - http://govome.inspsearch.com/search/web?fcoid=417&q=tophus r...
Tophus response to therapy for each subject - https://acr.confex.com/acr/2008/webprogram/Paper2306.html
¿Qué es un tofo gotoso? - http://govome.inspsearch.com/search/web?fcoid=417&q=medico -...
la respuesta al medicamento - http://govome.inspsearch.com/search/web?fcoid=417&fcop=topna...
Los objetivos del tratamiento son controlar el dolor y los ataques agudos y prevenir futuros episodios así como la formación de tofos y cálculos renales. - http://www.cdc.gov/arthritis/espanol/gout.htm
iponatremia, deshidratación, etc - http://www.cdc.gov/arthritis/espanol/gout.htm

spielenschach1
Portugal
Native speaker of: Native in PortuguesePortuguese
PRO pts in category: 8
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3 hrs
Reference: references to check

Reference information:
Hi Taous :) The "oral clearance" question has been asked and answered here before ... see the first link below.

To me, "aclaramiento oral" would work fine. I find it on a large enough number of web sites in a google search to make me trust it. Below is one example sentence I've found.

As to your other question (to answer before a moderator comes along and removes this) I think you'll find the exact translation on the site below, which my second link will take you to (go to section E.5.2.)

--------------------------------------------------
Note added at 3 hrs (2014-08-31 22:59:45 GMT)
--------------------------------------------------

Also found online:

"En pacientes tratados con inductores potentes del CYP3A4 (por ejemplo, la DFH, la carbamazepina y la ­rifampicina), aumentó el aclaramiento oral del ONDANSETRÓN y disminuyeron las concentraciones sanguíneas."

Example sentence(s):
  • En un estudio de dosis única, el aclaramiento oral (CL/F) disminuyó aproximadamente un 50 % en voluntarias con insuficiencia hepática moderada, comparado con las voluntarias con función hepática normal.

    Reference: http://www.proz.com/kudoz/english_to_spanish/medical%3A_phar...
    https://www.clinicaltrialsregister.eu/ctr-search/trial/2011-003767-29/ES
Joseph Tein
United States
Works in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 8
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612 days
Reference: EU Clinical Trial register

Reference information:
I know I am like 2 years late, but you should check this website:


    Reference: http://www.clinicaltrialsregister.eu/ctr-search/trial/2011-0...
LauraCavatorta
Belgium
Specializes in field
Native speaker of: Native in SpanishSpanish
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