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15:54 Apr 8, 2018
This question was closed without grading. Reason: Other
English to Spanish translations [PRO] Medical - Medical: Pharmaceuticals / Certificate of Analysis and conformance of a drug product
English term or phrase:meg/mg
Hola a todos:
La traducción es sobre los resultados del análisis de un producto farmacéutico y en una parte sale un cuadro que dice:
L Arginine Base Content
(DRUG NAME) Assay Corrected HPLC r-
y al lado de TEST sale SPECITICATIONS y abajo meg/mg
El texto tienen typos y en este cuadro está todo corrido, no sé si meg en meg/mg está bien y si pertenece a L Arginine Base Content o a (DRUG NAME) Assay Corrected HPLC r-
Alguien podría ayudarme con meg/mg? no encuentro nada en Internet.
Explanation: I need to revise this further but as far as HPLC correction goes I would guess that it could be expressed in mg/mg (en relación a pureza o contenido activo).
As said, I'll try to confirm.
* mEq would be a good guess for meg but I do not quite see it linked with either arginine measures or HPLC.
Sorry for this hurried answer anyhow!!
-------------------------------------------------- Note added at 9 hrs (2018-04-09 01:07:42 GMT) --------------------------------------------------
Just a few examples of mg/mg use in the (wide) context of HPLC;
%Purity = (100 - % HPLC impurities)*[(100-%moisture-%ROI-%RS)/100]
In the example above this yields a %purity of 98.2032. You will see that this would give 0.1968 mg for the 0.2% organic impurity value. Once you convert the %organic impurities to mg, you can see that the real value of the purity is 98.2032% via a subtraction equation. For a counter ion example, just subtract this in the numerator where the moisture is. The potency value here is usually expressed in mg/mg, so its answer is 0.982032 mg active/1 mg substance. http://www.chromforum.org/viewtopic.php?t=9503
The literature reveals that numerous analytical methods have been reported for the determination of gabapentin in pharmaceutical preparations and human serum.
Most of the HPLC assay procedures for the determination of gabapentin are based on the same approach, involving a simple automated O - phthaldehyde (OPA) derivatization followed by HPLC separation in acidic mobile phases and fluorometric detection.
Gabapentin (Vardhman Chemtech Ltd, Mohali, Punjab, India) used as an internal standard (0.9923 mg/mg) [Standardized with USP Gabapentin (0.999 mg/mg) Lot No GOEOO5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614759/
METHOD: HPLC (ref.: Acarbose, USP36)
Column: Supelcosil LC-NH2, 4.6 x 250mm, 5µm
Mobile Phase: Acetonitrile, 0.6g/L KH2PO4 and 0.35g/L Na2HPO4 in Water (72.5:27.5)
Flow Rate: 2mL/min
Column Temperature: 35ºC
ASSAY vs. USP CRS (anhydrous basis)
ASSAY VALUE vs. EP BATCH
Labeled Content = 0.981mg/mg https://www.google.es/url?sa=t&source=web&rct=j&url=https://...
Chema Nieto Castañón Spain Local time: 12:24 Specializes in field Native speaker of: Spanish PRO pts in category: 149