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English term or phrase:expressed on the chondrocytes
Result: 1.Granulation tissue around the cartilage:
a) CD68( monocyte/macrophage), CD 45(LCA), CD4 including fibroblastic cells were dominant in granulation tissues around the cartilage.
b) Proteolytic enzymes highly expressed on inflammatory cells around the cartilage were MMP-9, MMP-2, MMP-13, elastase and cathepsin L.
2. Cartilaginous tissues themselves:
c) Proteolytic enzymes remarkably expressed on the chondrocytes themselves were MMP-3 and cathepsin D.
d) Apoptotic phenomenon was demonstrated in chondrocytes themselves.
Summary: Cartilage destruction in polychondritis is induced not only by the inflammatory reaction around cartilage, but also the internal factors in chondrocytes themselves such as some kinds of proteolytic enzymes and apoptosis.