mer

Dutch translation: mer

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
French term or phrase:mer
Dutch translation:mer
Entered by: blomguib (X)

22:11 Jun 12, 2006
French to Dutch translations [PRO]
Science - Genetics
French term or phrase: mer
Phrase dans la description d'une préparation pharmaceutique: les séquences cibles d'ADN et d'ARN de 21 mer sont soulignées.

Wat wordt hier mee bedoeld? Een bepaalde zone van de sequentie, misschien?

Hulp wordt zoals steeds zeer gewaardeerd!
blomguib (X)
Local time: 14:02
mer
Explanation:
Un example:
http://ist.inserm.fr/BASIS/elgis/fqmr/rapp/DDD/550.pdf
Page 12:
Il est possible de recourir à des anti-sens ADN, natifs ou modifiés, d'anomérie β ou α. Ces ADN, généralement courts (20 à 30-mer), forment avec la séquence ARN-cible un hétéroduplex, suivi probablement par une dégradation subséquente du brin ARN par la RNase H. sauf dans le cas des ADN α qui donnent deshétéroduplex insensibles à cette enzyme.

In English too:
http://www.neb.com/nebecomm/products/productS1267.asp
PrimerN (30-mer)

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d...
Liposomal delivery of a 30-mer antisense oligodeoxynucleotide to inhibit proopiomelanocortin expression
An oligodeoxynucleic sequence of 30 bases (30-mer ODN), complementary to a region of beta-endorphin mRNA, was synthesized to have an antisense effect with regard to the expression of this oligopeptide. Following the solid-phase synthesis of the oligodeoxynucleotide, the 30-mer ODN was encapsulated within liposomes to provide a higher resistance against DNases and an improved entrance into cells. The most suitable liposome formulation as a 30-mer ODN carrier consisted of small unilamellar vesicles (50 nm) with an encapsulation capacity of 4.76 microL/micromol. The liposomal formulations containing dipalmitoyl-DL-alpha-phosphatidyl-L-serine presented fusogenic properties, which are of great importance for the delivery of antisense compounds. The antisense activity of 30-mer ODN-loaded liposomes was evaluated by the determination of beta-endorphin levels in AtT-20 cells. The free 30-mer ODN did not provide any lowering of the beta-endorphin production, whereas the liposomally entrapped compound elicited a concentration-dependent inhibition. The inhibition was determined by a sequence-specific binding of the 30-mer ODN with the target mRNA.

Voilà en Nederlands:
http://home.hetnet.nl/~tomhuls/folding/results.html
HET VOUWEN VAN EEN ALFA-HELIX GEBRUIKMAKEND VAN DISTRIBUTED DYNAMICS
(...)
20-mer van polyalanine: MPEG-filmpje -- 30-mer van polyalanine: MPEG-filmpje

--------------------------------------------------
Note added at 5 hrs (2006-06-13 04:10:52 GMT)
--------------------------------------------------

http://mailman.few.vu.nl/pipermail/fcsgroup-l/2005-April/000...
Bestelling: 0000146240

Uw ref Aantal Eh Kostenobject Omschrijving
---------- --------- --- ------------ ------------
1094654 1 EH 6405360 32-mer Oligonucleotide 50 nmol PCR
1094654 1 EH 6405360 30-mer Oligonucleotide 50 nmol PCR
Selected response from:

Fabio Descalzi
Uruguay
Local time: 13:02
Grading comment
merci beaucoup!
4 KudoZ points were awarded for this answer



Summary of answers provided
4mer
Fabio Descalzi


  

Answers


5 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
mer


Explanation:
Un example:
http://ist.inserm.fr/BASIS/elgis/fqmr/rapp/DDD/550.pdf
Page 12:
Il est possible de recourir à des anti-sens ADN, natifs ou modifiés, d'anomérie β ou α. Ces ADN, généralement courts (20 à 30-mer), forment avec la séquence ARN-cible un hétéroduplex, suivi probablement par une dégradation subséquente du brin ARN par la RNase H. sauf dans le cas des ADN α qui donnent deshétéroduplex insensibles à cette enzyme.

In English too:
http://www.neb.com/nebecomm/products/productS1267.asp
PrimerN (30-mer)

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d...
Liposomal delivery of a 30-mer antisense oligodeoxynucleotide to inhibit proopiomelanocortin expression
An oligodeoxynucleic sequence of 30 bases (30-mer ODN), complementary to a region of beta-endorphin mRNA, was synthesized to have an antisense effect with regard to the expression of this oligopeptide. Following the solid-phase synthesis of the oligodeoxynucleotide, the 30-mer ODN was encapsulated within liposomes to provide a higher resistance against DNases and an improved entrance into cells. The most suitable liposome formulation as a 30-mer ODN carrier consisted of small unilamellar vesicles (50 nm) with an encapsulation capacity of 4.76 microL/micromol. The liposomal formulations containing dipalmitoyl-DL-alpha-phosphatidyl-L-serine presented fusogenic properties, which are of great importance for the delivery of antisense compounds. The antisense activity of 30-mer ODN-loaded liposomes was evaluated by the determination of beta-endorphin levels in AtT-20 cells. The free 30-mer ODN did not provide any lowering of the beta-endorphin production, whereas the liposomally entrapped compound elicited a concentration-dependent inhibition. The inhibition was determined by a sequence-specific binding of the 30-mer ODN with the target mRNA.

Voilà en Nederlands:
http://home.hetnet.nl/~tomhuls/folding/results.html
HET VOUWEN VAN EEN ALFA-HELIX GEBRUIKMAKEND VAN DISTRIBUTED DYNAMICS
(...)
20-mer van polyalanine: MPEG-filmpje -- 30-mer van polyalanine: MPEG-filmpje

--------------------------------------------------
Note added at 5 hrs (2006-06-13 04:10:52 GMT)
--------------------------------------------------

http://mailman.few.vu.nl/pipermail/fcsgroup-l/2005-April/000...
Bestelling: 0000146240

Uw ref Aantal Eh Kostenobject Omschrijving
---------- --------- --- ------------ ------------
1094654 1 EH 6405360 32-mer Oligonucleotide 50 nmol PCR
1094654 1 EH 6405360 30-mer Oligonucleotide 50 nmol PCR


Fabio Descalzi
Uruguay
Local time: 13:02
Native speaker of: Native in SpanishSpanish
PRO pts in category: 4
Grading comment
merci beaucoup!
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