usage du gène producteur des chaînes lourdes d'immunoglobulines

13:14 Apr 27, 2018
This question was closed without grading. Reason: Other

French to English translations [PRO]
Medical - Medical (general) / Lab accreditation
French term or phrase: usage du gène producteur des chaînes lourdes d'immunoglobulines
Good morning,

This is in the description of an oncology test that is approved for this lab to perform under its new accreditation. I'm having trouble parsing this sentence...

The full sentence is:

Détermination du statut d'hypermutation et de l'usage VH du gène producteur des chaînes lourdes d'immunoglobulines dans une leucémie lymphoide chronique

What I know is that VH = heavy chain variable region genes
chaînes lourdes d'immunoglobulines = immunoglobulin heavy chains

I have come across "VH gene usage" and "use of VH genes"

But I'm having trouble putting it all together and I would appreciate your thoughts.

My attempt would be:

Determination of the hypermutation status and of VH gene usage in the gene producing immunoglobulin heavy chains in chronic lymphocytic leukemia

But I don't feel confident about it at all.

Thanks to anyone who might have some knowledge in this area!
Denise Pavao
United States
Local time: 19:55


Summary of answers provided
3Determination of hypermutational status and heavy chain immunoglobulin VH gene expression
Petra Neufing


  

Answers


31 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
de l\\\'usage du gène producteur des chaînes lourdes d\\\'immunoglobulines
Determination of hypermutational status and heavy chain immunoglobulin VH gene expression


Explanation:
Determination of hypermutational status and heavy chain immunoglobulin VH gene expression in chronic lymphocytic leukemia.
Normally "somatic" nature of mutation would be specified here. But I am not sure whether to add or not in this case as I am not sure of the extended context of the test. Whether we are talking about gene expression or somatic rearrangement is also not 100% sure from the limited context that we are given here. I would be able to help you more effectively if I could have a look at the test in question. In any case, I hope the following papers help you in your decision making.

https://www.researchgate.net/profile/Giovanni_Del_Poeta/publ...

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2141...


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Note added at 9 days (2018-05-06 15:38:52 GMT)
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Yes, I agree with you. Please write IgVH though (no capital G) in keeping with the accepted nomenclature.
Please find the following explanation from Wiki of the mechanism ("Usage" is the accepted term)
CLL Gene mutation status
IgVH mutation status
Prognosis varies greatly depending on into which diagnostic group CLL falls. The two[22] or three[23] prognostic groups are based on the maturational state of the cell. This distinction is based on the maturity of the lymphocytes as discerned by the immunoglobulin variable-region heavy chain (IgVH) gene mutation status.[24]High-risk patients have an immature cell pattern with few mutations in the DNA in the IgVH antibody gene region, whereas low-risk patients show considerable mutations of the DNA in the antibody gene region indicating mature lymphocytes.[25] Moreover, usage of specific subgenes (i.e. V3-21) for variable segment of immunoglobulin is a marker for more severe prognosis.[26] It is believed that the structure of variable subgenes of Ig and the whole surface immunoglobulin determines the propensity of chronic or tonic BCR signalling in CLL.[27] Additionally, the usage of certain variable segments (i.e. V2 family) is also connected to the activation of microRNA miR-650, which further influences the biology of CLL.[28][29]
Since assessment of the IgVH antibody DNA changes is difficult to perform, the presence of either CD38 or Z-chain–associated protein kinase-70 (ZAP-70) may be surrogate markers of high-risk subtype of CLL.[24] Their expression correlates positively with a more immature cellular state and a more rapid disease course.


Petra Neufing
France
Local time: 01:55
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 4
Notes to answerer
Asker: Thank you Petra. I appreciate your help with this question. The document did not include the actual test (just a list of tests the laboratory was approved to perform) so I wasn't able to give you any additional information.

Asker: I think it may be simply "usage of IGVH genes" : ) But I will continue to look into this a little further... Thanks again!

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