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|French to English translations [Non-PRO]|
Medical - Medical: Pharmaceuticals
|French term or phrase: médicament pâteux|
|This is a "guidelines" document on amendments to clinical trial protocol concerning any type of changes in the quality of the experimental drug. One of these changes is:|
"Modification du conditionnement d'un ME non liquide ou non pâteux, lorsque le ME n'est pas un médicament de thérapie génique ou de thérapie cellulaire."
**I'd like to ask only native English speakers to reply to this question.**
Selected response from:
Local time: 10:53
|Thanks so much for your help here!|
4 KudoZ points were awarded for this answer
29 mins confidence: peer agreement (net): +1
Multi-spike release formulation for oral drug delivery - Patent ...
The drug formulation may be in the form of a suspension, capsule, tablet, paste, gel, or solid or semi-solid form such as a “candy bar”. ...
www.freepatentsonline.com/6555127.html - 37k - Cached - Similar pages
Amlexanox paste is currently marketed in the United States under the trademark
Apthasol™ and is also available in Japan in a tablet formulation for the treatment of
asthma. A Notice of Compliance was received from the Therapeutic Products
Programme on December 11th, 2000. Paladin Labs Inc. would be the distributor of
this product in Canada and they expect to launch the product early in the year 2001.
At this time, the exact mechanism of action by which amlexanox causes accelerated
healing of aphthous ulcers is unknown. Amlexanox, an antiallergic agent, is a potent
inhibitor of the formation and/or release of inflammatory mediators from cells
including neutrophils and mast cells. As soon as a canker sore is discovered, a small
amount of paste (i.e., 0.5 cm) is applied four times daily to each ulcer. Treatment is
continued until the ulcer is healed. Should no significant healing or pain relief be
apparent after 10 days of use, medical or dental advice should be sought. Apthera® is
expected to be available as a 5% paste formulation in Canada.
Note added at 31 mins (2008-07-10 15:32:54 GMT)
WO94/25070 discloses oral composition containing a proton pump inhibitor in the form of enteric coated dry particles mixed with a dry gelling agent, the mixture may then be made into a paste-like gel prior to administration. The composition therefore requires enteric coating, with the afore-mentioned disadvantages associated with such formulation. Furthermore, because such a moist gel is not stable during long-term storage at room temperature it cannot be manufactured and sold as a ready-to-use formulation, rather it must be prepared ex tempore at the time of administration, making it inconvenient to use.
The formulation described herein is a stable, ready to use semi-solid paste formulation containing a proton pump inhibitor suitable for administering to animals such as horses, cattle, pig etc, and human beings with difficulty swallowing solid dosage forms such as tablets and capsules. The present invention can be easily administered to horses and is readily accepted by these animals. The formulation of the present invention is stable during long-term storage at room temperature.
| liz askew|
Local time: 09:53
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Native speaker of: English
PRO pts in category: 413
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|Changes made by editors|
|Jul 24, 2008 - Changes made by Drmanu49:|
|Created KOG entry||KudoZ term » KOG term|| |
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