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  2. German to English

pyrogenfrei

English translation: pyrogen-free

17:17 Sep 6, 2000
German to English translations [PRO]
Medical
German term or phrase: pyrogenfrei
Text about a device which removes fibrinogen from human plasma. The device is "pyrogenfrei"
Nick Smith, BA (Hons.), Dipl. Uebers. (FH Koeln)
United Kingdom
Local time: 12:17
English translation:pyrogen-free
Explanation:
pyrogens are parts of bacteria (chemically they are lipopolproteins) that remain in water or on parts even after sterilization. The immune system reacts to pyrogens, which is why they can cause fever (the word comes from greek and means causing fire). Obviously, in anything that is injected or implanted into the human body, no pyrogens may be present, so a device used to treat plasma (which is then used to produce injectable drugs) has to be pyrogen-free. The common test for pyrogens is the LAL-Assay, which indicates endotoxin units, with 0.25 EU being the maximum admissible for injectables (and 0.03 the lower detection limit)
Selected response from:

Uta Moerschell (X)
Local time: 13:17
Grading comment
Thanks v. much. Nick.
4 KudoZ points were awarded for this answer



Summary of answers provided
nasee below
Elisabeth Moser
napyrogen-free
Parrot
napyrogen-free
Uta Moerschell (X)


  

Answers


2 mins
see below


Explanation:
pyrogen free or free of pyrogen
pyrogen=Any substance that produces
fever


    Taber's Medical Dictionary
Elisabeth Moser
United States
Local time: 07:17
Native speaker of: Native in GermanGerman
PRO pts in pair: 786
Login to enter a peer comment (or grade)

21 mins
pyrogen-free


Explanation:
Before a drug is launched on the market it is required to pass a pyrogen test to assure consumers that it does not cause fevers or intoxications.

Parrot
Spain
Local time: 13:17
Native speaker of: English
PRO pts in pair: 315
Login to enter a peer comment (or grade)

12 hrs
pyrogen-free


Explanation:
pyrogens are parts of bacteria (chemically they are lipopolproteins) that remain in water or on parts even after sterilization. The immune system reacts to pyrogens, which is why they can cause fever (the word comes from greek and means causing fire). Obviously, in anything that is injected or implanted into the human body, no pyrogens may be present, so a device used to treat plasma (which is then used to produce injectable drugs) has to be pyrogen-free. The common test for pyrogens is the LAL-Assay, which indicates endotoxin units, with 0.25 EU being the maximum admissible for injectables (and 0.03 the lower detection limit)

Uta Moerschell (X)
Local time: 13:17
Native speaker of: Native in GermanGerman
PRO pts in pair: 37
Grading comment
Thanks v. much. Nick.
Login to enter a peer comment (or grade)



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