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Tyrosylresten

English translation: Tyrosyl residues

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
German term or phrase:Tyrosylresten
English translation:Tyrosyl residues
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10:06 Aug 16, 2001
German to English translations [PRO]
Medical
German term or phrase: Tyrosylresten
Rezeptor- Tyrosinkinasen, die Proteine (auch der eigenen Art) an den OH-Gruppen von Tyrosylresten phosphorylieren
Desre Derda
Switzerland
Local time: 00:35
tyrosine residues
Explanation:
From first link below:

Protein Kinases

The yeast genome contains about 7,000 ORFs, of which over 100 (about 2%) are protein kinases. This makes kinases the second most abundant family of proteins, second only to transcriptional regulators. Genomic data on C. elegans and Drosophila melanogaster shows that about 2% of the ORFs of those genomes are also kinases and current estimates are that the human genome, of an estimated ~100,000 ORFs, will also contain about 2% kinases, giving ~2,000 human protein kinases. Clearly this is an extremely abundant family of proteins. Eukaryotic kinases catalyze the addition of phosphate groups to protein side chains with free hydroxyl groups, which are serine, threonine and tyrosine. They use ATP for this and need magnesium also, and they generate ADP, so they can be regarded as ATPases. The consequences of phosphorylation are to alter at least the local charge on the protein which is phosphorylated. This in turn can lead to conformation changes which may alter the enzymatic properties, stability or binding properties of the protein. Phosphorylation on tyrosine residues in particular leads to the generation of specific binding sites for SH2 domains and Ptb domains (see below), directly permitting specific protein-protein interactions to take place.

From second link below:

The protein kinase/kinase-associated receptors include at least three families of receptors:

1. tyrosine-specific protein kinase receptors- these receptors phosphorylate proteins on the hydroxyl groups of tyrosine residues (e.g., insulin receptor).

2. serine-threonine kinase receptors- these receptors phosphorylate proteins on the hydroxyl groups of either serine or threonine residues (e.g., receptor for transforming growth factor-b).

3. tyrosine kinase-associated receptors- these receptors phosphorylate proteins at tyrosine residues indirectly by activating membrane-bound or cytosolic tyrosine kinases (e.g., growth hormone receptor)







Selected response from:

Marcus Malabad
Canada
Local time: 00:35
Grading comment
Thanks very much for your help
Regards Des
4 KudoZ points were awarded for this answer

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Summary of answers provided
na +3tyrosyl residues!Marcus Malabad
na -1tyrosine residuesMarcus Malabad


  

Answers


16 mins peer agreement (net): -1
tyrosine residues


Explanation:
From first link below:

Protein Kinases

The yeast genome contains about 7,000 ORFs, of which over 100 (about 2%) are protein kinases. This makes kinases the second most abundant family of proteins, second only to transcriptional regulators. Genomic data on C. elegans and Drosophila melanogaster shows that about 2% of the ORFs of those genomes are also kinases and current estimates are that the human genome, of an estimated ~100,000 ORFs, will also contain about 2% kinases, giving ~2,000 human protein kinases. Clearly this is an extremely abundant family of proteins. Eukaryotic kinases catalyze the addition of phosphate groups to protein side chains with free hydroxyl groups, which are serine, threonine and tyrosine. They use ATP for this and need magnesium also, and they generate ADP, so they can be regarded as ATPases. The consequences of phosphorylation are to alter at least the local charge on the protein which is phosphorylated. This in turn can lead to conformation changes which may alter the enzymatic properties, stability or binding properties of the protein. Phosphorylation on tyrosine residues in particular leads to the generation of specific binding sites for SH2 domains and Ptb domains (see below), directly permitting specific protein-protein interactions to take place.

From second link below:

The protein kinase/kinase-associated receptors include at least three families of receptors:

1. tyrosine-specific protein kinase receptors- these receptors phosphorylate proteins on the hydroxyl groups of tyrosine residues (e.g., insulin receptor).

2. serine-threonine kinase receptors- these receptors phosphorylate proteins on the hydroxyl groups of either serine or threonine residues (e.g., receptor for transforming growth factor-b).

3. tyrosine kinase-associated receptors- these receptors phosphorylate proteins at tyrosine residues indirectly by activating membrane-bound or cytosolic tyrosine kinases (e.g., growth hormone receptor)










    Reference: http://www.ufbi.ufl.edu/~shaw/lecture-1.htm
    Reference: http://www.pharm.sc.edu/Clasp/404re.htm
Marcus Malabad
Canada
Local time: 00:35
Native speaker of: Native in EnglishEnglish, Native in TagalogTagalog
PRO pts in pair: 1782
Grading comment
Thanks very much for your help
Regards Des

Peer comments on this answer (and responses from the answerer)
disagree  DR. RICHARD BAVRY: makes me 'yl"
3 days 15 hrs
Login to enter a peer comment (or grade)

20 mins peer agreement (net): +3
tyrosyl residues!


Explanation:
Des, sorry, I misread the question. It's tyrosyl and NOT the above answer.


    Reference: http://www.biology.iastate.edu/Courses/Zool%20355/Lecture%20...
    Reference: http://www.bumc.bu.edu/Departments/PageMain.asp?Page=2825&De...
Marcus Malabad
Canada
Local time: 00:35
Native speaker of: Native in EnglishEnglish, Native in TagalogTagalog
PRO pts in pair: 1782

Peer comments on this answer (and responses from the answerer)
agree  Roland Grefer
1 hr

agree  Sven Petersson
3 hrs

agree  DR. RICHARD BAVRY: there ya go! We will make a chemist of you yet!
3 days 14 hrs
Login to enter a peer comment (or grade)




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