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thrombozytenständig

English translation: thrombocyte cyclooxygenase

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
German term or phrase:thrombozytenständige Cyclooxygenase
English translation:thrombocyte cyclooxygenase
Entered by: Steffen Walter
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17:23 Oct 30, 2007
German to English translations [PRO]
Medical - Medical (general)
German term or phrase: thrombozytenständig
in a patent about a transdermal patch delivering acetylslicylic acid or salicylic acid through the skin. This part relates to prior art.

Der dabei erzielte Wirkstoff-Flux entspricht aber im Hinblick auf den zeitlichen Eintritt und das Ausmaß der beabsichtigten pharmakologischen Wirkungen, beispielsweise hinsichtlich einer frühestmöglichen Inaktivierung der thombozytenständigen Cyclooxygenase, nicht den gestellten Erwartungen.
Christine Lam
Local time: 07:35
thrombocyte-cyclooxygenae
Explanation:
meaning, cyclooxygenase present in thrombocyes..


Aspirin inhibits cyclooxygenase and thus prostaglandin synthesis. The drug has analgesic, anti-inflammatory and antipyretic effects. Through its effect on the ** thrombocyte-cyclooxygenase ** it inhibits the formation of a highly effective platelet aggregator and a vasoconstrictor (thromboxane A2). Since the platelets do not synthesize proteins, the effect remains demonstrable as long as the affected thrombocytes live (7-10 days).

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Note added at 13 mins (2007-10-30 17:36:21 GMT)
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Sorry - should be "cyclooxygenase".

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Note added at 14 mins (2007-10-30 17:38:02 GMT)
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his paper introduces the contribution of EPA to blood flow failure prevention through the action mechanism of the anti-thrombus and anti-arteriosclerosis action of EPA as the EFA of n-3 system. As the anti-thrombus function of EPA, the following are known: Platelet aggregation inhibitory effect, production of PGI3, improvement of serum lipid, and erythrocyte deformability. The platelet aggregation inhibitory effect includes direct action and indirect action, and EPA suppresses the production of TXA2 derived from AA in thrombocytes. The following five platelet aggregation inhibitory effects are considered to contribute to blood flow failure. (1) Control of PG ** cyclooxygenase in thrombocytes **. (2) Decrease in AA content in platelet membrance phospholipid. (3) Production of TXA3X with weak platelet aggregation activity from EPA. (4) Decrease in PGI2 derived from AA in the vessel wall. (5) Production of PGI3 with equivalent platelet aggregation inhibitory activity with PGI2 from EPA.
Selected response from:

Zareh Darakjian Ph.D.
United States
Local time: 04:35
Grading comment
thank you so much!
4 KudoZ points were awarded for this answer

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Summary of answers provided
3 +3thrombocyte-cyclooxygenaeZareh Darakjian Ph.D.


Discussion entries: 1





  

Answers


10 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +3
thrombocyte-cyclooxygenae


Explanation:
meaning, cyclooxygenase present in thrombocyes..


Aspirin inhibits cyclooxygenase and thus prostaglandin synthesis. The drug has analgesic, anti-inflammatory and antipyretic effects. Through its effect on the ** thrombocyte-cyclooxygenase ** it inhibits the formation of a highly effective platelet aggregator and a vasoconstrictor (thromboxane A2). Since the platelets do not synthesize proteins, the effect remains demonstrable as long as the affected thrombocytes live (7-10 days).

--------------------------------------------------
Note added at 13 mins (2007-10-30 17:36:21 GMT)
--------------------------------------------------

Sorry - should be "cyclooxygenase".

--------------------------------------------------
Note added at 14 mins (2007-10-30 17:38:02 GMT)
--------------------------------------------------

his paper introduces the contribution of EPA to blood flow failure prevention through the action mechanism of the anti-thrombus and anti-arteriosclerosis action of EPA as the EFA of n-3 system. As the anti-thrombus function of EPA, the following are known: Platelet aggregation inhibitory effect, production of PGI3, improvement of serum lipid, and erythrocyte deformability. The platelet aggregation inhibitory effect includes direct action and indirect action, and EPA suppresses the production of TXA2 derived from AA in thrombocytes. The following five platelet aggregation inhibitory effects are considered to contribute to blood flow failure. (1) Control of PG ** cyclooxygenase in thrombocytes **. (2) Decrease in AA content in platelet membrance phospholipid. (3) Production of TXA3X with weak platelet aggregation activity from EPA. (4) Decrease in PGI2 derived from AA in the vessel wall. (5) Production of PGI3 with equivalent platelet aggregation inhibitory activity with PGI2 from EPA.

Zareh Darakjian Ph.D.
United States
Local time: 04:35
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in ArmenianArmenian
PRO pts in category: 377
Grading comment
thank you so much!

Peer comments on this answer (and responses from the answerer)
agree  Dr Sue Levy
28 mins
  -> Thank you very much, Dr. Levy!

agree  Dr. Roy Bheekha
13 hrs
  -> Thank you, very much, Dr. Bheekha!

agree  xxxDr.G.MD
7 days
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Changes made by editors
Oct 31, 2007 - Changes made by Steffen Walter:
Edited KOG entry<a href="/profile/34047">Steffen Walter's</a> old entry - "thombozytenständige Cyclooxygenase" » "thrombocyte cyclooxygenase"
Oct 31, 2007 - Changes made by Steffen Walter:
Edited KOG entry<a href="/profile/73754">Christine Lam's</a> old entry - "thrombozytenständig" » "thrombocyte-cyclooxygenae"


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