Δείκτης πνευμονικής / καρδιακής καθήλωσης

English translation: Pulmonary / cardiac uptake index

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Greek term or phrase:Δείκτης πνευμονικής / καρδιακής καθήλωσης
English translation:Pulmonary / cardiac uptake index
Entered by: Rebecca Inghammar Chatzidimitriou

19:05 Nov 15, 2007
Greek to English translations [PRO]
Medical - Medical: Cardiology / Σπινθηρογράφημα καρδιάς
Greek term or phrase: Δείκτης πνευμονικής / καρδιακής καθήλωσης
Ο δείκτης πνευμονικής / καρδιακής καθήλωσης υπολογίσθηκε σε 0,59 (φ.τ
Rebecca Inghammar Chatzidimitriou
Sweden
Local time: 21:56
Pulmonary / cardiac uptake index
Explanation:
Το "uptake" πολλές φορές ταυτίζεται με την "πρόσληψη" αλλά στα ισότοπα το βλέπω και με την έννοια της "συγκέντρωσης".
Καλή συνέχεια.

Computer-based quantitative analysis of gallium-67 uptake in normal and diseased lungs
G Bisson, G Drapeau, G Lamoureux, A Cantin, M Rola-Pleszczynski and R Begin
To study the 67Ga *lung uptake* as an index of inflammatory activity, we developed a computer-based method to process the data obtained from the 67Ga scan. Background radioactivity below the kidneys was subtracted from counts in all areas and given a score of 0; the maximal liver uptake was scored as 16. Radioactivity over six lung fields was scored by the computer between 0 and 16 and averaged to yield a mean 67Ga lung uptake index. This index of 67Ga lung accumulation correlates with histopathologic scores of inflammation in lung tissue and with bronchoalveolar lavage (BAL) levels of 67Ga radioactivity retrieval. This study reports the quantitative analysis of 67Ga lung uptake in normal subjects and patients with various pulmonary diseases. This method provides an objective index of inflammatory activity in lung tissues, and it is simple, sensitive, and discriminative.
http://www.chestjournal.org/cgi/content/abstract/84/5/513

Όπως ήδη αναφέραμε η θεραπευτική χορήγηση 131Ι αφορά τα λειτουργούντα καλώς διαφοροποιημένα καρκινώματα θηλώδη και θυλακιώδη. Τα θηλώδη καρκινώματα όπως είναι γνωστό κατά κανόνα εμπεριέχουν και θυλακιώδη στοιχεία στα οποία κυρίως οφείλεται η πρόσληψη και η κατακράτηση του 131Ι. [...] Η ακτινοβολία αυτή για να φέρει το επιθυμητό αποτέλεσμα πρέπει να παραληφθεί και να κατακρατηθεί από όγκο όσο το δυνατόν μικρότερου μεγέθους.
[...] Η καθήλωση του 131Ι πρέπει να είναι σε ποσοστό μεγαλύτερο του 1% της χορηγούμενης δόσεως ώστε να ακτινοβολήσει τον νεοπλασματικό ιστό με αρκετή δόση ραδιενέργειας για να επιφέρει το επιθυμητό αποτέλεσμα που είναι η πλήρης καταστροφή του νεοπλασματικού ιστού
[...] ο σπινθηρογράφημα αυτό μπορεί να συγκριθεί με το επόμενο ολόσωμο σπινθηρογράφημα που μπορεί να γίνει μετά από 6-9 μήνες και με την τιμή της θυρεοσφαιρίνης που θα γίνει τότε οπότε και αποφασίζεται αν ο ασθενής πρέπει να λάβει και δεύτερη θεραπευτική δόση όταν η τιμή της θυρεοσφαιρίνης παραμένει υψηλή και το τελευταίο σπινθηρογράφημα δείχνει καθήλωση του 131Ι στον τράχηλο, στους πνεύμονες, στα οστά κλπ.
[...]
Positron emission tomography, imaging with Thallium-201, and Technetium-99m Sestamibi can identify a small number of patients shown to have metastasis from well differentiated thyroid carcinoma by increasing thyroglobulin levels in the absence of 131Ι uptake.

Abnormal Uptake of Tc-99m MIBI, A Novel Myocardial Imaging Agent, in the Lungs of Patients With Systemic Sclerosis.
Original Articles
Clinical Nuclear Medicine. 23(1):19-25, January 1998.
RICHARD, MICHAEL M.D., Ph.D. *; COX, DARRIN M.D. +; EARLE, LINDA M.D. +; VARGA, JOHN M.D. +
Abstract:
Objective: Fibrosing alveolitis is a prominent feature of systemic sclerosis (SSc), and accounts for much of the morbidity and mortality of this disease. Sensitive techniques for the detection and monitoring of fibrosing alveolitis could target patients for early therapeutic intervention. The objective of this small pilot study was to assess the frequency and clinical significance of abnormal lung uptake of Tc-99m MIBI, a novel radionuclide imaging agent that selectively accumulates in cells rich in mitochondria.
Methods: Sixteen patients with SSc and evidence of pulmonary involvement were studied. The uptake of radionuclide in the lungs, and the **ratio of pulmonary to cardiac uptake** were evaluated after intravenous injection of Tc-99m MIBI. Results were correlated with clinical and laboratory parameters.
Results: Lung uptake of Tc-99m MIBI was increased in all 16 SSc patients compared to control patients with coronary heart disease but no evidence of pulmonary abnormality. The degree of isotope uptake in the lungs was correlated with the extent of maximal skin induration and with radiologic evidence of interstitial lung disease, but not with other clinical or laboratory parameters of disease activity or extent of pulmonary involvement. **The ratio of pulmonary to cardiac uptake** of isotope was also increased in patients with SSc compared to controls.
Conclusion: Accumulation of Tc-99m MIBI is abnormally elevated in the lungs of SSc patients with pulmonary involvement. Isotope accumulation in the lungs may be related to activation of fibroblasts or endothelial cells. The specificity and sensitivity of Tc-99m MIBI scanning in the detection and monitoring of pulmonary involvement, and its potential role in the management of SSc, deserve further investigation.
http://www.nuclearmed.com/pt/re/cnm/abstract.00003072-199801...

Unilateral left pulmonary Tl-201 uptake on raw data images of dual-isotope
http://linkinghub.elsevier.com/retrieve/pii/S107135810400391...

ncreased pulmonary uptake of Tl-201 chloride on stress imaging has been well documented as an additional diagnostic and prognostic value.
http://linkinghub.elsevier.com/retrieve/pii/S107135810400451...

Tl-201 Iung uptake in 74 patients (85 lesions) and pulmonary perfusion in 105 patients were studied to evaluate clinical usefulness of Tl-201 lung uptake and perfusion lung scintigraphy in pulmonary tuberculosis
http://sciencelinks.jp/j-east/article/200014/000020001400A03...

An increased non-cardiac uptake of Thallium-201 (Tl-201). and Tc-99m sestamibi (MIBI) may be seen on the cine view of. myocardial perfusion single photon...
http://www.anakarder.com/sayilar/21/2005-140-141.pdf

Myocardial Imaging with Thallium-201: Effect of Cardiac Drugs

Propranolol reduced Tl-201 uptake in cardiac tissue by a statistically significant but small amount, also consistent with the M/Bk data.
http://jnm.snmjournals.org/cgi/content/abstract/19/1/10




--------------------------------------------------
Note added at 20 hrs (2007-11-16 15:56:47 GMT)
--------------------------------------------------

Να προσθέσω ότι αποδίδεται και με το απλούστερο "lung / heart uptake index"
Selected response from:

Katerina Athanasaki
Local time: 22:56
Grading comment
Thanks Katerina. Your answer is exactly what I was looking for :-)
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +1Pulmonary / cardiac uptake index
Katerina Athanasaki


Discussion entries: 4





  

Answers


20 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
Pulmonary / cardiac uptake index


Explanation:
Το "uptake" πολλές φορές ταυτίζεται με την "πρόσληψη" αλλά στα ισότοπα το βλέπω και με την έννοια της "συγκέντρωσης".
Καλή συνέχεια.

Computer-based quantitative analysis of gallium-67 uptake in normal and diseased lungs
G Bisson, G Drapeau, G Lamoureux, A Cantin, M Rola-Pleszczynski and R Begin
To study the 67Ga *lung uptake* as an index of inflammatory activity, we developed a computer-based method to process the data obtained from the 67Ga scan. Background radioactivity below the kidneys was subtracted from counts in all areas and given a score of 0; the maximal liver uptake was scored as 16. Radioactivity over six lung fields was scored by the computer between 0 and 16 and averaged to yield a mean 67Ga lung uptake index. This index of 67Ga lung accumulation correlates with histopathologic scores of inflammation in lung tissue and with bronchoalveolar lavage (BAL) levels of 67Ga radioactivity retrieval. This study reports the quantitative analysis of 67Ga lung uptake in normal subjects and patients with various pulmonary diseases. This method provides an objective index of inflammatory activity in lung tissues, and it is simple, sensitive, and discriminative.
http://www.chestjournal.org/cgi/content/abstract/84/5/513

Όπως ήδη αναφέραμε η θεραπευτική χορήγηση 131Ι αφορά τα λειτουργούντα καλώς διαφοροποιημένα καρκινώματα θηλώδη και θυλακιώδη. Τα θηλώδη καρκινώματα όπως είναι γνωστό κατά κανόνα εμπεριέχουν και θυλακιώδη στοιχεία στα οποία κυρίως οφείλεται η πρόσληψη και η κατακράτηση του 131Ι. [...] Η ακτινοβολία αυτή για να φέρει το επιθυμητό αποτέλεσμα πρέπει να παραληφθεί και να κατακρατηθεί από όγκο όσο το δυνατόν μικρότερου μεγέθους.
[...] Η καθήλωση του 131Ι πρέπει να είναι σε ποσοστό μεγαλύτερο του 1% της χορηγούμενης δόσεως ώστε να ακτινοβολήσει τον νεοπλασματικό ιστό με αρκετή δόση ραδιενέργειας για να επιφέρει το επιθυμητό αποτέλεσμα που είναι η πλήρης καταστροφή του νεοπλασματικού ιστού
[...] ο σπινθηρογράφημα αυτό μπορεί να συγκριθεί με το επόμενο ολόσωμο σπινθηρογράφημα που μπορεί να γίνει μετά από 6-9 μήνες και με την τιμή της θυρεοσφαιρίνης που θα γίνει τότε οπότε και αποφασίζεται αν ο ασθενής πρέπει να λάβει και δεύτερη θεραπευτική δόση όταν η τιμή της θυρεοσφαιρίνης παραμένει υψηλή και το τελευταίο σπινθηρογράφημα δείχνει καθήλωση του 131Ι στον τράχηλο, στους πνεύμονες, στα οστά κλπ.
[...]
Positron emission tomography, imaging with Thallium-201, and Technetium-99m Sestamibi can identify a small number of patients shown to have metastasis from well differentiated thyroid carcinoma by increasing thyroglobulin levels in the absence of 131Ι uptake.

Abnormal Uptake of Tc-99m MIBI, A Novel Myocardial Imaging Agent, in the Lungs of Patients With Systemic Sclerosis.
Original Articles
Clinical Nuclear Medicine. 23(1):19-25, January 1998.
RICHARD, MICHAEL M.D., Ph.D. *; COX, DARRIN M.D. +; EARLE, LINDA M.D. +; VARGA, JOHN M.D. +
Abstract:
Objective: Fibrosing alveolitis is a prominent feature of systemic sclerosis (SSc), and accounts for much of the morbidity and mortality of this disease. Sensitive techniques for the detection and monitoring of fibrosing alveolitis could target patients for early therapeutic intervention. The objective of this small pilot study was to assess the frequency and clinical significance of abnormal lung uptake of Tc-99m MIBI, a novel radionuclide imaging agent that selectively accumulates in cells rich in mitochondria.
Methods: Sixteen patients with SSc and evidence of pulmonary involvement were studied. The uptake of radionuclide in the lungs, and the **ratio of pulmonary to cardiac uptake** were evaluated after intravenous injection of Tc-99m MIBI. Results were correlated with clinical and laboratory parameters.
Results: Lung uptake of Tc-99m MIBI was increased in all 16 SSc patients compared to control patients with coronary heart disease but no evidence of pulmonary abnormality. The degree of isotope uptake in the lungs was correlated with the extent of maximal skin induration and with radiologic evidence of interstitial lung disease, but not with other clinical or laboratory parameters of disease activity or extent of pulmonary involvement. **The ratio of pulmonary to cardiac uptake** of isotope was also increased in patients with SSc compared to controls.
Conclusion: Accumulation of Tc-99m MIBI is abnormally elevated in the lungs of SSc patients with pulmonary involvement. Isotope accumulation in the lungs may be related to activation of fibroblasts or endothelial cells. The specificity and sensitivity of Tc-99m MIBI scanning in the detection and monitoring of pulmonary involvement, and its potential role in the management of SSc, deserve further investigation.
http://www.nuclearmed.com/pt/re/cnm/abstract.00003072-199801...

Unilateral left pulmonary Tl-201 uptake on raw data images of dual-isotope
http://linkinghub.elsevier.com/retrieve/pii/S107135810400391...

ncreased pulmonary uptake of Tl-201 chloride on stress imaging has been well documented as an additional diagnostic and prognostic value.
http://linkinghub.elsevier.com/retrieve/pii/S107135810400451...

Tl-201 Iung uptake in 74 patients (85 lesions) and pulmonary perfusion in 105 patients were studied to evaluate clinical usefulness of Tl-201 lung uptake and perfusion lung scintigraphy in pulmonary tuberculosis
http://sciencelinks.jp/j-east/article/200014/000020001400A03...

An increased non-cardiac uptake of Thallium-201 (Tl-201). and Tc-99m sestamibi (MIBI) may be seen on the cine view of. myocardial perfusion single photon...
http://www.anakarder.com/sayilar/21/2005-140-141.pdf

Myocardial Imaging with Thallium-201: Effect of Cardiac Drugs

Propranolol reduced Tl-201 uptake in cardiac tissue by a statistically significant but small amount, also consistent with the M/Bk data.
http://jnm.snmjournals.org/cgi/content/abstract/19/1/10




--------------------------------------------------
Note added at 20 hrs (2007-11-16 15:56:47 GMT)
--------------------------------------------------

Να προσθέσω ότι αποδίδεται και με το απλούστερο "lung / heart uptake index"

Katerina Athanasaki
Local time: 22:56
Specializes in field
Native speaker of: Greek
PRO pts in category: 16
Grading comment
Thanks Katerina. Your answer is exactly what I was looking for :-)

Peer comments on this answer (and responses from the answerer)
agree  Mirjana Popovic Kirkontzogloy
21 days
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