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薬剤誘起性肝障害を引き起こすことが

English translation: [compounds which are known] to cause drug-induced liver injury

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08:54 Dec 11, 2010
Japanese to English translations [PRO]
Medical - Medical: Pharmaceuticals / genetics
Japanese term or phrase: 薬剤誘起性肝障害を引き起こすことが
そこで本研究では,過去,薬剤誘起性肝障害を引き起こすことが既知な化合物であるacetaminophenとtxoglitazoneの[14^]標識体を用いて,反応性代謝物のヒト肝ミクロソーム蛋白への共有結合量と,GSTM1およびGSTT1の遺伝子型との関係を調べることにより,反応性代謝物の生成量とGSTを介したグルタチオン抱合による解毒能力とのバランスが,反応性代謝物の蛋白への共有結合量,ひいては肝毒性発現を決定する可能性があるという仮説を立て,検証を行うことを目的とした。

In the above sentence I am not understanding where to put 薬剤誘起性肝障害を引き起こすこと.
My translation is as below.


In this research, in the past, we aimed at reviewing a hypothesis which said covalent binding of reactive metabolite protein and thus hepatotoxicity expression can be fixed by maintaining the balance with detoxification capability by glutathione conjugation through reactive metabolite production quantity and GST. This hypothesis was achieved by finding covalent binding of human liver microsome protein of reactive metabolite and genetic type relationship of GSTM1 and GSTT1 using [14C] labeled acetaminophen and txoglitazone which are known compounds, causing drug induced liver injury.


Any suggestions would be appreciated.

Thanks
Champak16
Local time: 18:46
English translation:[compounds which are known] to cause drug-induced liver injury
Explanation:
You need to take 薬剤誘起性肝障害を引き起こすことが with 既知な化合物であるacetaminophenとtxoglitazone.

「X (verb)することが既知なY (noun) 」= 「X (verb)することが既に知られているY (noun)」

So acetaminophen and troglitazone are not exactly ‘known compounds which cause ~’ but ‘compounds which are known to cause ~’.

I assume that txoglitazone is a typo for troglitazone.

So my proposed translation of the relevant section (薬剤誘起性肝障害を引き起こすことが既知な化合物であるacetaminophenとtxoglitazoneの[14^]標識体を用いて) is as follows:

“by using labelled acetaminophen and troglitazone[14^], compounds which are known to cause drug-induced liver injury,”

I’m not going to comment on the rest of the paragraph as I’m not a specialist.
Selected response from:

Tomoyuki Kono
United Kingdom
Local time: 13:16
Grading comment
ありがとうございます。
4 KudoZ points were awarded for this answer

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Summary of answers provided
3[compounds which are known] to cause drug-induced liver injury
Tomoyuki Kono


  

Answers


1 day 12 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
[compounds which are known] to cause drug-induced liver injury


Explanation:
You need to take 薬剤誘起性肝障害を引き起こすことが with 既知な化合物であるacetaminophenとtxoglitazone.

「X (verb)することが既知なY (noun) 」= 「X (verb)することが既に知られているY (noun)」

So acetaminophen and troglitazone are not exactly ‘known compounds which cause ~’ but ‘compounds which are known to cause ~’.

I assume that txoglitazone is a typo for troglitazone.

So my proposed translation of the relevant section (薬剤誘起性肝障害を引き起こすことが既知な化合物であるacetaminophenとtxoglitazoneの[14^]標識体を用いて) is as follows:

“by using labelled acetaminophen and troglitazone[14^], compounds which are known to cause drug-induced liver injury,”

I’m not going to comment on the rest of the paragraph as I’m not a specialist.

Tomoyuki Kono
United Kingdom
Local time: 13:16
Specializes in field
Native speaker of: Native in JapaneseJapanese
PRO pts in category: 4
Grading comment
ありがとうございます。
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