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Soarta conjugatilor in organism (reactii de conjugare de faza a IIIa)

English translation: Metabolization/Modification of conjugates in the human body (phase III conjugation reactions)

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08:07 Feb 24, 2012
Romanian to English translations [PRO]
Medical - Medical: Pharmaceuticals / conjugati
Romanian term or phrase: Soarta conjugatilor in organism (reactii de conjugare de faza a IIIa)
Este vorba despre programa analitica a Facultatii de Farmacie.
Adriana Dragomir
Local time: 09:40
English translation:Metabolization/Modification of conjugates in the human body (phase III conjugation reactions)
Explanation:
Atat substantele intrate in organismul uman cat si cele endogene sunt supuse metabolizarii, adica transformarii, de aceea "soarta" se poate traduce astfel. Pentru conformitatea terminologiei folosite am adaugat doua link-uri. Inserez mai jos un citat de pe primul site:

Phase III - further modification and excretion

After phase II reactions, the xenobiotic conjugates may be further metabolised. A common example is the processing of glutathione conjugates to acetylcysteine (mercapturic acid) conjugates.

Conjugates and their metabolites can be excreted from cells in phase III of their metabolism, with the anionic groups acting as affinity tags for a variety of membrane transporters of the multidrug resistance protein (MRP) family. These proteins are members of the family of ATP-binding cassette transporters and can catalyse the ATP-dependent transport of a huge variety of hydrophobic anions, and thus act to remove phase II products to the extracellular medium, where they may be further metabolised or excreted.
Selected response from:

Ioana Popa
Romania
Local time: 09:40
Grading comment
Multumesc mult
4 KudoZ points were awarded for this answer

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Summary of answers provided
4 +2Metabolization/Modification of conjugates in the human body (phase III conjugation reactions)
Ioana Popa


Discussion entries: 2





  

Answers


36 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +2
Metabolization/Modification of conjugates in the human body (phase III conjugation reactions)


Explanation:
Atat substantele intrate in organismul uman cat si cele endogene sunt supuse metabolizarii, adica transformarii, de aceea "soarta" se poate traduce astfel. Pentru conformitatea terminologiei folosite am adaugat doua link-uri. Inserez mai jos un citat de pe primul site:

Phase III - further modification and excretion

After phase II reactions, the xenobiotic conjugates may be further metabolised. A common example is the processing of glutathione conjugates to acetylcysteine (mercapturic acid) conjugates.

Conjugates and their metabolites can be excreted from cells in phase III of their metabolism, with the anionic groups acting as affinity tags for a variety of membrane transporters of the multidrug resistance protein (MRP) family. These proteins are members of the family of ATP-binding cassette transporters and can catalyse the ATP-dependent transport of a huge variety of hydrophobic anions, and thus act to remove phase II products to the extracellular medium, where they may be further metabolised or excreted.


    Reference: http://en.wikipedia.org/wiki/Xenobiotic_metabolism
    Reference: http://www.ncbi.nlm.nih.gov/pubmed/20817760
Ioana Popa
Romania
Local time: 09:40
Specializes in field
Native speaker of: Native in RomanianRomanian
PRO pts in category: 4
Grading comment
Multumesc mult

Peer comments on this answer (and responses from the answerer)
agree  Irina-Maria Foray
11 hrs
  -> Multumesc mult!

agree  Claudia Coja: Makes sense:)
4 days
  -> Multumesc mult! :-)
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