gestrinona

English translation: Gestrinone

11:06 Aug 10, 2000
Spanish to English translations [PRO]
Medical
Spanish term or phrase: gestrinona
One of the components of a medicine used to treat endometriosis.
piao
Local time: 15:26
English translation:Gestrinone
Explanation:
Gestrinone
Dimetriose (Roussel Uclaf)
2.5 mg capsules

Indication: endometriosis
Gestrinone is a synthetic steroid hormone which inhibits the release of pituitary gonadotrophins. The effect on ovarian secretion results in the atrophy of endometrial tissue, including regression of endometriosis. Gestrinone is structurally related to norgestrel and has some androgenic and progestogenic activity. However, the drug has an antiprogesterone effect on endometrial tissue.

The halflife is approximately 27 hours and a steady state is achieved if a second capsule is taken 3 days after the first dose. The drug is metabolised and the metabolites are excreted in the urine and faeces.

Treatment begins on the first day of a period and continues for 6 months. Most women develop amenorrhoea within two months. If spotting occurs, the dose can be increased to one capsule 3 times a week for a few weeks. Repeat courses of gestrinone are not recommended.

Although gestrinone is effective in relieving the symptoms of endometriosis, its effect on infertility is not clear. The efficacy of the drug is probably similar to danazol.

Like danazol, many of gestrinone's adverse effects are due to its androgenic activity. These include acne, seborrhoea, hirsutism, weight gain and changes to the voice. Most patients will have at least one adverse event. Although gestrinone inhibits ovulation, patients need to use barrier contraception while taking the drug. This is because the drug is embryotoxic in some animals and can cause masculinisation of a female fetus. Gestrinone also significantly reduces HDL concentrations.
Selected response from:

Laura Gentili
Italy
Local time: 16:26
Grading comment
Thank you very much for a most useful answer (please forgive me for taking so long - but I had honestly believed I had selected your answer earlier).
Kind regards,
Mila
4 KudoZ points were awarded for this answer



Summary of answers provided
naGestrinone
Laura Gentili
nagestrinone
Joan Wallace (X)


  

Answers


9 mins
gestrinone


Explanation:
From Dorland's:

gestrinone - chemical name: 13-ethyl-17-hydroxy18,19-dinor-17alpha-pregna-4.9-11-trien-20-yn-3-one; a progestin C21H24O2 (sorry, can't do subscript here).


    Dorland's Illustrated Medical Dictionary
Joan Wallace (X)
PRO pts in pair: 59

Peer comments on this answer (and responses from the answerer)
Heathcliff
Login to enter a peer comment (or grade)

12 mins
Gestrinone


Explanation:
Gestrinone
Dimetriose (Roussel Uclaf)
2.5 mg capsules

Indication: endometriosis
Gestrinone is a synthetic steroid hormone which inhibits the release of pituitary gonadotrophins. The effect on ovarian secretion results in the atrophy of endometrial tissue, including regression of endometriosis. Gestrinone is structurally related to norgestrel and has some androgenic and progestogenic activity. However, the drug has an antiprogesterone effect on endometrial tissue.

The halflife is approximately 27 hours and a steady state is achieved if a second capsule is taken 3 days after the first dose. The drug is metabolised and the metabolites are excreted in the urine and faeces.

Treatment begins on the first day of a period and continues for 6 months. Most women develop amenorrhoea within two months. If spotting occurs, the dose can be increased to one capsule 3 times a week for a few weeks. Repeat courses of gestrinone are not recommended.

Although gestrinone is effective in relieving the symptoms of endometriosis, its effect on infertility is not clear. The efficacy of the drug is probably similar to danazol.

Like danazol, many of gestrinone's adverse effects are due to its androgenic activity. These include acne, seborrhoea, hirsutism, weight gain and changes to the voice. Most patients will have at least one adverse event. Although gestrinone inhibits ovulation, patients need to use barrier contraception while taking the drug. This is because the drug is embryotoxic in some animals and can cause masculinisation of a female fetus. Gestrinone also significantly reduces HDL concentrations.


Laura Gentili
Italy
Local time: 16:26
Native speaker of: Native in ItalianItalian
PRO pts in pair: 38
Grading comment
Thank you very much for a most useful answer (please forgive me for taking so long - but I had honestly believed I had selected your answer earlier).
Kind regards,
Mila

Peer comments on this answer (and responses from the answerer)
Yvette Camou
Login to enter a peer comment (or grade)



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