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| 09:36 Feb 7, 2008 |
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| Spanish language (monolingual) [PRO] Medical - Medical: Health Care / análisis | |||||||
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| SUMMARY OF ALL EXPLANATIONS PROVIDED | ||||
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Answers
4 hrs confidence: 
ver Explanation: J. Alberola, A. Tamarit and D. Navarro Department of Microbiology, School of Medicine, University of Valencia, Spain. Antibodies mediating post-attachment virus neutralisation (PN), inhibition of human cytomegalovirus (HCMV)-induced cell fusion in the glioblastoma cell line U373 (IF) and global neutralising activity (NA) were quantified in sera from healthy immunocompetent individuals, asymptomatic HIV-1-infected subjects and AIDS patients to further characterise the neutralising antibody response to HCMV in these population groups and to assess whether HIV-1-infected individuals exhibited an abnormal functional antibody profile. PN and IF antibodies accounted for a minor fraction of the NA activity of sera from all population groups. Sera from HIV-1-infected individuals (particularly AIDS patients) displayed higher levels of PN and IF antibodies than those from the healthy control group; however, the relative contribution of these antibodies to the global serum NA activity appeared to be lower in the former individuals than in immunocompetent controls. Serum antibodies preventing HCMV cell-to-cell spread (IP) were then measured to determine whether a specific deficiency could be detected in the HIV-1-infected group population. Serum IP antibody titres were significantly higher in HIV-1-infected individuals (particularly in AIDS patients) than in controls. The potential implications of the data for explaining the pathogenesis of HCMV infection are discussed. -------------------------------------------------- Note added at 4 hrs (2008-02-07 13:52:52 GMT) -------------------------------------------------- ANTIBODY TITER KINETICS The analysis of anti–B burgdorferi IgG and IgM antibodies before and after antibiotic therapy in the 113 study patients identified 3 distinct profiles of titer kinetics for each antibody class: persistence of a positive antibody titer throughout the observation period (PP), persistence of a negative antibody titer throughout the observation period (PN), -------------------------------------------------- Note added at 4 hrs (2008-02-07 13:55:30 GMT) -------------------------------------------------- P = Positivo N = Negativo ?? http://216.239.59.104/search?q=cache:YPymHFBvSxIJ:sisbib.unm... Hope you can work this one out ;) |
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