intracerebral hemorrhage has perforated into [invaded] the frontal and occipital ventricular horns
Your text talks about cerebral ventricles, which need to be differentiated from the cardiac ventricles. The cerebral ventricles have prolongations also called "horns" (astas, in Sp).
The test report here says that the cerebral hemorrhage of the frontal area has perforated into (or invaded, filled) the frontal ventricular prolongation/horn and has gone as far back as the occipital prolongation/horn.
Imaizumi S. Onuma T. Mino M. Kameyama M. Motohashi O. Free hand aspiration for large periventricular hemorrhage.
Case report. Surgical Neurology. 55(6):376-7, 2001
BACKGROUND: At present, there are several therapeutic options, including craniotomy and stereotactic aspiration, for large **intracerebral hemorrhage perforating into the lateral ventricle**. In the cases with Glasgow Coma Scale (GCS) scores under 6 with anisocoria, external ventricular drainage would be the first choice [2-4]. We have also performed anterior **ventricular horn** puncture in a standard manner. The target was the foramen of Monro, at a depth of 5.5 cm from the inner table of the skull. The point of insertion was located just anterior to the coronal suture, approximately 10 cm above the nasion, and 3 cm from the midline and 2 over black square]; [1 and 2 over black square]]. However, we noticed that the insertion of a catheter into the periventricular hematoma adjacent to the lateral ventricle was made easier by tilting the catheter 30 degrees laterally as in the first case (Figure 1). METHODS: In our method, inclining the catheter by 30 degrees laterally, we used a silicone tube 3.5 mm in internal diameter (Silascon ventricle drainage tube, Kaneka Medix Corp., Osaka, Japan) and then replaced it with another Silascon tube with a 2.5 mm-internal diameter. From January 1999 through December 2000, eleven patients who all had GCS scores under 6 and anisocoria preoperatively were treated by this method. The series included two patients who were undergoing hemodialysis because of renal failure, two with bleeding tendency because of liver dysfunction, and one with heart failure. RESULTS: The insertion itself caused no complications. Cerebrospinal fluid was drained smoothly after removal of hematoma because the hematoma cavity connecting with the lateral ventricle was opened. Two typical cases using this technique are shown (Figures 1 and 2). All patients recovered favorable consciousness postoperatively compared with the preoperative state but hemiparesis remained. Postsurgical follow up at 3 months revealed the outcomes evaluated by Glasgow Outcome Scale (GOS) were moderate disability in 5 patients and severe disability in 6 patients. CONCLUSION: This direct aspiration and drainage of a large intracerebral hematoma that ruptures into the lateral ventricle is superior to simple ventricular drainage in regard to the removal of the hematoma clot. This technique would be the choice especially in patients with serious complications such as cardiac disease and renal failure.
Holtzman RN. Brust JC. Ainyette IG. Bowers PP. Tikofsky RS. Lliguin HM. Hughes JE. Acute **ventricular hemorrhage** in adults with hydrocephalus managed by corpus callosotomy and fenestration of the septum pellucidum. Report of three cases. Journal of Neurosurgery. 95(1):111-5, 2001
Nestin is an intermediate filament protein found in CNS progenitor cells. Nestin reappears in CNS tumor cells and reactive astrocytes after CNS injury. In this study we investigated whether nestin could be detected in the cerebrospinal fluid (CSF) of newborn infants and whether expression levels change with gestational age (GA) and/or brain injury. Using Western blot analysis, we examined the expression of nestin in the CSF of newborn infants (GA 25-42 wk) with asphyxia (n = 14), periventricular leukomalacia and **peri(intra)ventricular hemorrhage** (n = 7), and in a control group (n = 11). Protein extract from the periventricular brain tissue of a 1-wk-old infant was also analyzed. Nestin was detected in all the CSF samples and in the protein extract from the periventricular brain tissue.