procedimiento de estaadiaje único de Fleming
English translation: Fleming's single-stage procedure
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| 13:00 Nov 5, 2003 |
| Spanish to English translations [PRO] Medical / clinical trial protocol, drug therapy | |||||||
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|  Selected response from: Elena Sgarbo (X) | ||||||
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| 4 +2 | Fleming's [standard] single-stage test procedure |
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| 4 | Fleming's one-sample multiple testing procedure |
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Answers
10 mins confidence: 
| procedimiento de estaadiaje único de Fleming Fleming's one-sample multiple testing procedure Explanation: See if this is the one (Phase II Trials). -------------------------------------------------- Note added at 27 mins (2003-11-05 13:27:45 GMT) -------------------------------------------------- The Mayo Clinic has the bibliography (NIH abstract files open very slowly): http://www.mayo.edu/hsr/techrpt.html Reference: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d... |
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48 mins confidence: peer agreement (net): +2
peer agreement (net): +2Fleming's [standard] single-stage test procedure Explanation: Parrot is on the right track with her response, but I believe the text refers only to a part of the "one-sample multiple testing procedure". That part is the last one of the multiple testing , i.e., the last test, called "single stage". Good luck Elena One-sample multiple testing procedure for phase II clinical trials. Fleming TR. Commonly, the central objective of Phase II clinical trials is the assessment of the antitumor 'therapeutic efficacy' of a specific treatment regimen. It is of interest to formulate test procedures which can be employed in these trials to decide whether or not this therapeutic efficacy warrants further investigation. For ethical reasons, these procedures should allow for early termination if initial results are extreme. In this paper, a one-sample multiple testing procedure is proposed which employs the **standard single-stage test procedure** at the last test, and which both allows for early termination and essentially preserves the size, power and simplicity of the **single-stage procedure**. |
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