Las relaciones de dosificación en ratas al NOAEL
English translation: relationships of dosage in rats to
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| 15:06 Oct 20, 2006 |
| Spanish to English translations [PRO] Medical - Medical (general) / Research report for new drug | |||||||
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|  Selected response from: Carol Gullidge United Kingdom Local time: 20:03 | ||||||
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| Discussion entries: 4 | |
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Answers
3 mins confidence: 
peer agreement (net): +1
peer agreement (net): +1relationships of dosage in rats to Explanation: I think you were already there! dosage:noael |
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1 hr confidence: 
Dose response at fertility and developmental no-observable-effect level (NOAEL) in rats ... Explanation: Dose response at fertility and developmental no-observable-effect level (NOAEL) in rats ranged from .... (If "no-observable-effect level (NOAEL)" has already been used in the document, then put only the acronym: Dose response at fertility and developmental NOAEL in rats ranged from .... maternal and developmental no-observable-effect levels (NOAELs) of 125 and >250 mg/kg/day, respectively, were established for MMDHCA. A complementary analysis of all dose responses assessed by hypothesis testing or distributional analyses, where the units of comparison were treatment doses below the NOAEL, revealed that of 1089 doses below the NOAEL http://toxsci.oxfordjournals.org/cgi/content/full/62/2/330 Chemical Information System - IRISA NOAEL is an experimentally determined ***dose***at which there was no statistically ... Empirical observations have generally revealed that as the dosage of a ... www.nisc.com/cis/details/iris-description.htm |
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18 hrs confidence:
the exposure ratios using the NOAEL for rats for fertility and development (effects) ranged between Explanation: See this extract below. Note that the tertminology seems to be "exposure ratio" (do a search in Google with NOAEL, MHRD, etc as other keywords) and phrasing goes "using XXXX in <type of animal>" Therefore, the relative animal:human *exposure ratios* *using the LOAEL in rats*, and MHRD or RHD in humans are 25 and 100, respectively; and *using the NOAEL in rats*, and MHRD or RHD in humans are 6.25 and 25, respectively. a = concern is increased for relative exposure ratios (animal:human) that are ? 10, and are decreased for *exposure ratios* ? 25. Ratios between 10-25 are not associated with any change in the perception of concern for this factor. FROM: R. W. Johnson Pharmaceutical Research Institute Therefore, the relative animal:human exposure ratios using the LOAEL in rats, and MHRD or RHD in humans are 25 and 100, respectively; and using the NOAEL in ... www.fda.gov/ohrms/dockets/DOCKETS/99n2079/ts00005/tsld020.h... - 3k - Cached - Similar pages -------------------------------------------------- Note added at 18 hrs (2006-10-21 09:45:30 GMT) -------------------------------------------------- Rephrasing to avoid the double "for", and the first one should be "in" anyway:-): Using/based on the NOAEL in rats for fertility and development (effects), the exposure rates observed ranged between ....... |
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