SMP G2

English translation: hand-foot syndrome - grade2

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20:52 May 6, 2018
Spanish to English translations [PRO]
Medical - Medical (general) / Lung cancer reports
Spanish term or phrase: SMP G2
This term is included in a report from Mexico by an oncologist, for a patient with lung cancer. Lots of idiosyncratic doctor shorthand, abbreviations, etc. There is no real immediate context for this term, but I'm including a considerable chunk of the report below:

X, masculino de 74 años con el Dx de Carcinoma epidermoide moderadamente diferenciado. EC IIIA por T3 tumor a menos de 2 cm de la carina N2 por adenopatías mediastinales ipsilateral, QT de inducción 2 ciclos Carbo Paclitaxel QT/RT 34Fx con 6 semanas carbo Paclitaxel, finalizo el dia 30 de mayo 2017.
Actual acude a QT de consolidación por 2 ciclos. lndicamos primer ciclo de carbo Paclitaxel. Acude a valorar el ciclo numero 2 de consolidación

Se Refiere Fatigado, entumecimiento de manos y pies

Toxicidades. ***SMP G2***, Fatiga g1, Debilidad g1,

Signos vitales TA 131/65 FC 66 FR 19 SO2 96% Peso 76.5 77.5 Talla 1.68 SC 1.90 A la EF en regulares condiciones generales, no datos de insuficiencia respiratoria, campos pulmonares con murmullo vesicular normal, no sibilancias.

I think the "G2" (& "g1" in following terms) are from standard terminology for the phases of the cell cycle (?). But I haven't been able to run anything down on "SMP".
Any help will be greatly appreciated.
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Like 13
TomWalker
United States
Local time: 07:28
English translation:hand-foot syndrome - grade2
Explanation:
Resultados. Se incluyeron 93 pts (45 BC/48 CRC) tratados previamente. 31 presentaron toxicidad grado 3-4: síndrome mano-pie (SMP) 15%,

https://www.seom.org/seomcms/images/stories/recursos/sociosy...

Page 6
Frequency of toxicity in descending order were fatigue, hand-foot syndrome (palmar-plantar erythrodysesthesia, PPE), diarrhoea and nausea that inflicted on the majority of patients and often led to dose reduction and discontinuation of treatment.

https://www.tandfonline.com/doi/pdf/10.1080/0284186050037521...

Page 2
grade definition
G1 minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain
G2 skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limitinginstrumental activities daily living
G3 severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self care activities of daily living

Page 3
Those patients who were in contact with their oncology nurses and followed the recommendations had fiftyfold lower lower risk of developing hand-foot syndrome G2 or G3 as compared to the patients who did not cooperate.

http://www.wple.net/plek/numery_2016/numer-7-2016/460-464.pd...

Many of the published clinical trials of agents associated with hand-foot syndrome were initiated prior to the introduction of a standard grading scheme. In capecitabine trials, hand-foot syndrome has been graded 1 to 3, based on functional criteria: Grade 1 was defined as numbness, dysesthesia/paresthesia, tingling, painless swelling, or erythema not disrupting normal activities; grade 2 was defined as painful erythema with swelling that disrupts daily activities; and grade 3 was defined as moist desquamation, ulceration, blistering, severe pain, or any symptoms leading to an inability to perform daily activities.

http://www.cancernetwork.com/breast-cancer/coming-grips-hand...


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Note added at 5 days (2018-05-12 16:46:02 GMT) Post-grading
--------------------------------------------------

Tom, I'm glad to have helped. Thank you for your kind words!
Selected response from:

Helena Chavarria
Spain
Local time: 16:28
Grading comment
Great answer as usual, Helena. Well-explained, clear, brief & to the point, with helpful references. Thanks a lot.
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +4hand-foot syndrome - grade2
Helena Chavarria


  

Answers


20 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +4
hand-foot syndrome - grade2


Explanation:
Resultados. Se incluyeron 93 pts (45 BC/48 CRC) tratados previamente. 31 presentaron toxicidad grado 3-4: síndrome mano-pie (SMP) 15%,

https://www.seom.org/seomcms/images/stories/recursos/sociosy...

Page 6
Frequency of toxicity in descending order were fatigue, hand-foot syndrome (palmar-plantar erythrodysesthesia, PPE), diarrhoea and nausea that inflicted on the majority of patients and often led to dose reduction and discontinuation of treatment.

https://www.tandfonline.com/doi/pdf/10.1080/0284186050037521...

Page 2
grade definition
G1 minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain
G2 skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limitinginstrumental activities daily living
G3 severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self care activities of daily living

Page 3
Those patients who were in contact with their oncology nurses and followed the recommendations had fiftyfold lower lower risk of developing hand-foot syndrome G2 or G3 as compared to the patients who did not cooperate.

http://www.wple.net/plek/numery_2016/numer-7-2016/460-464.pd...

Many of the published clinical trials of agents associated with hand-foot syndrome were initiated prior to the introduction of a standard grading scheme. In capecitabine trials, hand-foot syndrome has been graded 1 to 3, based on functional criteria: Grade 1 was defined as numbness, dysesthesia/paresthesia, tingling, painless swelling, or erythema not disrupting normal activities; grade 2 was defined as painful erythema with swelling that disrupts daily activities; and grade 3 was defined as moist desquamation, ulceration, blistering, severe pain, or any symptoms leading to an inability to perform daily activities.

http://www.cancernetwork.com/breast-cancer/coming-grips-hand...


--------------------------------------------------
Note added at 5 days (2018-05-12 16:46:02 GMT) Post-grading
--------------------------------------------------

Tom, I'm glad to have helped. Thank you for your kind words!

Helena Chavarria
Spain
Local time: 16:28
Native speaker of: Native in EnglishEnglish
PRO pts in category: 280
Grading comment
Great answer as usual, Helena. Well-explained, clear, brief & to the point, with helpful references. Thanks a lot.

Peer comments on this answer (and responses from the answerer)
agree  Charles Davis: I was just putting an answer together myself! The abbreviation HFS is commonly used. / Not to worry! I was going to give it confidence 3, but actually I think it must be right, so the research (not that much) was not wasted.
10 mins
  -> Charles, I'm sorry you've done a lot of research for nothing but thank you for your agreement. I wasn't 100% sure it was right!

agree  Clare Peartree
13 mins
  -> Thank you, Clare :-)

agree  lorenab23: Muy bien Helenita!
1 hr
  -> Thank you, Lorena :-)

agree  George Simon: Very nicely explained Helena
1 hr
  -> George, that's very kind of you. Thank you :-)
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