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antibiótico padre

English translation: parent antibiotic

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GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Spanish term or phrase:antibiótico padre
English translation:parent antibiotic
Entered by: sebaspedlp
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16:35 Dec 30, 2016
Spanish to English translations [PRO]
Medical - Medical: Pharmaceuticals / trabajo para facultad
Spanish term or phrase: antibiótico padre
del grupo hidroxilo 7 (R) del antibiótico padre, lincomycin. Inhibe la síntesis proteica de la bacteria a nivel ribosomal. El antibiótico se une preferentemente a la subunidad ribosomal 50S y afecta el proceso de iniciación de la cadena peptídica. Lincomycin es un antibiótico que combate las bacterias.

Lincomycin se usa para tratar las infecciones bacterianas severas en los pacientes que no pueden usar antibióticos tipo penicilina.

Lincomycin se usa sólo para infecciones severas. Esta medicina no va a tratar una infección viral como el resfrío común o la gripe.

Lincomycin puede también usarse para fines no mencionados en esta guía del medicamento.

¿Cuál es la información más importante que debo saber sobre lincomycin?
Lincomycin se usa sólo para infecciones severas. Esta medicina no va a tratar una infección viral como el resfrío común o la gripe.

Los medicamentos antibióticos pueden causar un sobrecrecimiento de bacterias normalmente inofensivas en los intestinos. Esto puede llevar a una infección que puede causar diarrea leve a severa, inclusive meses después de que usted tomó su última dosis del antibiótico. Llame a su médico al primer signo de diarrea durante o al poco tiempo después de su tratamiento con lincomycin.
sebaspedlp
Argentina
Local time: 16:21
parent antibiotic
Explanation:
Clindamycin phosphate topical solution, for external use, contains clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per milliliter in a hydroalcoholic solution. Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

http://www.accessdata.fda.gov/spl/data/df3fdd8e-0c49-47f6-a8...

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Note added at 50 mins (2016-12-30 17:26:18 GMT)
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Dihydrostreptomycin is a derivative and is used as an alternative to the parent antibiotic.

http://medical-dictionary.thefreedictionary.com/streptomycin

For most antibiotics, a defined exposure– toxicity relationship does not always exist. In these scenarios, one must make an empirical decision about how much accumulation (AUC24SS), and thus the theoretical amount of toxicity, is acceptable. Accumulation should be assessed at the CLCR level immediately prior to the dose adjustment threshold, because this is the point of maximum accumulation for the parent antibiotic regimen.

http://jac.oxfordjournals.org/content/65/11/2285.full.pdf


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Note added at 53 mins (2016-12-30 17:28:53 GMT)
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This approach allows the preparatively useful generation of a series of antibiotics with increased lipophilicity over that of the parent antibiotic.

http://pubs.rsc.org/en/content/articlehtml/2015/sc/c5sc02919...

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Note added at 1 day23 hrs (2017-01-01 15:45:34 GMT) Post-grading
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It's my pleasure. Happy New Year to you, too!
Selected response from:

Helena Chavarria
Spain
Local time: 21:21
Grading comment
Happy new year! And thank you so much!
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +2parent antibiotic
Helena Chavarria


  

Answers


42 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +2
parent antibiotic


Explanation:
Clindamycin phosphate topical solution, for external use, contains clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per milliliter in a hydroalcoholic solution. Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin.

http://www.accessdata.fda.gov/spl/data/df3fdd8e-0c49-47f6-a8...

--------------------------------------------------
Note added at 50 mins (2016-12-30 17:26:18 GMT)
--------------------------------------------------

Dihydrostreptomycin is a derivative and is used as an alternative to the parent antibiotic.

http://medical-dictionary.thefreedictionary.com/streptomycin

For most antibiotics, a defined exposure– toxicity relationship does not always exist. In these scenarios, one must make an empirical decision about how much accumulation (AUC24SS), and thus the theoretical amount of toxicity, is acceptable. Accumulation should be assessed at the CLCR level immediately prior to the dose adjustment threshold, because this is the point of maximum accumulation for the parent antibiotic regimen.

http://jac.oxfordjournals.org/content/65/11/2285.full.pdf


--------------------------------------------------
Note added at 53 mins (2016-12-30 17:28:53 GMT)
--------------------------------------------------

This approach allows the preparatively useful generation of a series of antibiotics with increased lipophilicity over that of the parent antibiotic.

http://pubs.rsc.org/en/content/articlehtml/2015/sc/c5sc02919...

--------------------------------------------------
Note added at 1 day23 hrs (2017-01-01 15:45:34 GMT) Post-grading
--------------------------------------------------

It's my pleasure. Happy New Year to you, too!

Helena Chavarria
Spain
Local time: 21:21
Native speaker of: Native in EnglishEnglish
PRO pts in category: 72
Grading comment
Happy new year! And thank you so much!
Notes to answerer
Asker: Thank you so much


Peer comments on this answer (and responses from the answerer)
agree  Marie Wilson
34 mins
  -> Thank you, Marie!

agree  Muriel Vasconcellos
14 hrs
  -> Thank you, Muriel :-) Happy New Year!
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