English to Chin: Cardiovascular disease General field: Medical Detailed field: Medical (general) | |
Source text - English Cardiovascular disease (CV) is the most common cause of premature mortality in patients with rheumatoid ar-thritis (RA). This is the result of an accelerated atherosclerotic process. Adequate CV risk tratification has special relevance in RA to identify patients at risk of CV disease. However, current CV risk screening and management strategies underestimate the actual CV risk in RA. Consequently, the
search for additional tools that may help to identify those patients at high CV risk has become a key objective in the last years. In this regard, non-invasive surrogates, such as carotid ultrasonography, have been found to be excellent predictors of future CV events. In addition, several studies have revealed the relevance of a genetic component in the development of CV disease in RA patients. Besides an association with HLA-DRB1* shared epitope alleles other gene polymor-phisms located inside and outside the HLA seem to influence the risk of cardiovascular disease in RA. Moreover, serum levels of some metabolic syndrome-related biomarkers, adipokines such as adiponectin and biomarkers of endothelial cell activation and inflammation such as Osteoprotegerin and Asymmetric dimethylarginine have re-cently been found useful for the prediction of CV disease in these patients. An update of the current knowledge on these potential markers, especially focused on new genetic and serological biomarkers is shown in this review. | Translation - Chin 简介:在印度Punjab地区因恶性肿瘤而死亡的人群中,食管癌是导致其现象的首要原因。食管癌的病人通常以吞咽困难为首发症状,但是更多的人群直至晚期才出现吞咽困难。姑息性治疗对其着重要的作用。对于吞咽困难症状严重的食管癌病人来说,置入食管支架是缓解吞咽困难的最佳治疗方案。
目的:旨在了解应用食管支架置入在食管癌食管狭窄病患者中的成功率,及其置入早期和晚期患者的并发症和死亡率。 |
Chinese to English: Abstract | |
Source text - Chinese 摘要:[目的]探讨家族性多发内分泌腺瘤病 1 型(multiple endocrine
neoplasia type 1,MEN1)的发病特点、诊断流程和治疗原则。[方法]
对我院近期诊治的一组多发内分泌腺瘤病 1 型家系的临床表现、诊断要
点、治疗方法和转归进行总结分析。[结果] 同一家族中 3 个病例被先
后诊断为 MEN1,并通过基因检测发现一种新的 MEN1 基因突变位点。针
对甲状旁腺功能亢进均给予手术治疗,术后一月随访甲状旁腺激素水平
均恢复正常。 [结论] 家族性 MEN1 的诊断包括临床诊断、家族史和
基因诊断 3 个方面。治疗上需要多学科讨论治疗方案,针对甲状旁腺功
能亢进的,甲状旁腺次全切除或全切除+甲状旁腺种植是指南推荐的标
准手术方案,但目前对于年轻的早期病人仍有一定争议。 | Translation - English Abstract: To explore the pathogenesis features, diagnose procedures
and the therapeutic principle of familial Multiple Endocrine Neoplasia
type 1(MEN1). Method: A group cases of familial MEN1’s clinical
presentation, diagnostic points, management method, outcome were
analysed and summarized, which came from the recent cases that were
been diagnosed and treated in our hospital. Result: Three people in the same clan was diagnosed as MEN1
successively, we identified a new mutation in MEN1 gene by Genetic
Testing.Due to the hyperparathyroidism, the surgery was performed and
the level of parathyroid hormone returned to normal 1 month after.
Conclusion: The diagnosis of familial MEN1 including three
aspects, clinical diagnosis, familial history and Genetic Testing.We
came to the conclusion that multidisciplinary cooperation should be
promoted.To those patients with hyperthyroidism, the total or sum total
excision of the parathyroid gland with parathyroid implantation were
the standard surgery options which were recommended by the official guide. But it is controversial when it comes to the patient at the young age and in a primitive stage. |