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English to Portuguese: Tenofovir alafenamide monofumarate nonclinical toxicology General field: Medical Detailed field: Medical (general)
Source text - English Nonclinical Toxicology
Tenofovir alafenamide monofumarate (GS-7340-02) was evaluated in mice, rats, dogs, and monkeys for treatment periods up to 9 months and was negative in genetic toxicology studies.
In chronic studies in rats, bone (atrophy of metaphyseal cancellous bone) and kidneys (karyomegaly) were the primary target organs after 26 weeks of treatment. GS 7340 02 also appeared to increase biochemical markers of bone turnover and decrease serum 1,25 dihydroxy and 25 hydroxyvitamin D3 at doses of 25 mg/kg/day and above. In chronic studies in dogs after 9 months of treatment with GS 7340 02, the primary target organs were kidney and bone.
GS-7340-02 had no discernible ECG effect at the low dose of 2 mg/kg/day and slightly prolonged PR intervals at 6 and 18/12 mg/kg/day (started at 18 mg/kg/day, then reduced to 12 mg/kg/day at Weeks 7-8). Additionally, at Week 39, GS 7340 02 appeared to reversibly reduce heart rate with an associated mild QT prolongation. At Week 39, decreases in serum triiodothyronine (T3) were noted for animals receiving 18/12 mg/kg/day but was reversible at the 3 month recovery period. Minor hematological and biochemistry parameters changes were observed but remained within normal historical ranges with the following exceptions: aspartate aminotransferase {AST (~ 100% increase)} and total bilirubin (~ 40% increase). There were no clear treatment-related effects observed in monkeys following 28 days of treatment, including no changes in mitochondrial function.
Translation - Portuguese Toxicologia não clínica
Monofumarato de tenofovir alafenamida (GS-7340-02) foi avaliado em camundongos, ratos, cães e macacos em períodos de tratamento de até nove meses e teve resultado negativo em estudos de toxicologia genética.
Em estudos crônicos em ratos, os ossos (atrofia do osso esponjoso metafisário) e os rins (cariomegalia) foram os principais órgãos-alvo após 26 semanas de tratamento. GS-7340-02 aparentemente também aumentou os marcadores bioquímicos da remodelação óssea e diminuiu os níveis séricos de 1,25 di-hidroxivitamina D3 e 25 hidroxivitamina D3 em doses de 25 mg/kg/dia e superiores. Em estudos crônicos em cães, após nove meses de tratamento com GS-7340-02, os principais órgãos-alvo foram os rins e os ossos.
GS-7340-02 não apresentou um efeito discernível no ECG sob dose baixa de 2 mg/kg/dia, e apresentou intervalos PR ligeiramente prolongados de 6 e 18/12 mg/kg/dia (iniciado em 18 mg/kg/dia, depois reduzido para 12 mg/kg/dia nas Semanas 7-8). Além disso, na Semana 39, GS-7340-02 aparentemente reduziu de forma reversível a frequência cardíaca com um ligeiro prolongamento do intervalo QT relacionado. Na Semana 39, foram observadas diminuições na triiodotironina sérica (T3) em animais que receberam 18/12 mg/kg/dia, mas houve reversão no período de recuperação de três meses. Foram observadas pequenas alterações nos parâmetros hematológicos e bioquímicos, mas que permaneceram dentro das faixas históricas normais, com as seguintes exceções: aspartato aminotransferase {AST (~ 100% de aumento)} e bilirrubina total (~ 40% de aumento). Não foram observados efeitos claramente relacionados ao tratamento em macacos após 28 dias de tratamento, incluindo nenhuma alteração na função mitocondrial.
English to Portuguese: Error messages (antivirus) General field: Tech/Engineering Detailed field: IT (Information Technology)
Source text - English Error messages (Antivirus)
Error: "2222" after I install my Antivirus
Run the fix tool
The tool to automatically fix this problem is available in the Support Center. Support Center starts automatically when your antivirus encounters this error. We recommend that you restart the computer, and if the error persists, follow the instructions to run the automated fix in Support Center.
Message: "Activation not complete”
Run Update Tool
Start your Antivirus
In the Computer screen, click Run Update Tool.
When the Update Tool is finished, click OK.
Run the Update Tool until you see the message, "Update Tool finished - No updates found".
Translation - Portuguese Mensagens de erro (antivírus)
Erro: “2222” após a instalação do Antivírus
Executar a ferramenta de correção
A ferramenta que repara esse problema de forma automática está disponível no Centro de Suporte. O Centro de Suporte inicia automaticamente quando o antivírus identifica esse erro. Recomendamos que reinicie o computador, e se o erro persistir, siga as instruções para executar a correção automática no Centro de Suporte.
Mensagem: “Ativação não concluída”
Executar Ferramenta de Atualização
Inicie o Antivírus
Na tela do computador, clique em Executar Ferramenta de Atualização.
Quando a Ferramenta de Atualização estiver concluída, clique em OK.
Execute a Ferramenta de Atualização até ver a mensagem “Ferramenta de Atualização concluída – nenhuma atualização encontrada”.
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Translation education
Bachelor's degree - University of Brasilia
Experience
Years of translation experience: 5. Registered at ProZ.com: Mar 2019. Became a member: Aug 2019.
English to Portuguese (Universidade de Brasília - Departamento de Línguas Estrangeiras e Tradução, verified) Portuguese to English (Universidade de Brasília - Departamento de Línguas Estrangeiras e Tradução, verified)
Graduated in Translation from the University of Brasília in 2014, I have worked for a couple of years in the public sector, including the Federal Senate Translation and Interpretation Service, the FIFA Broadcast Service Team, the University of Brasília and the Ministry of Foreign Affairs of Bangladesh.
Since 2019 I have been providing freelance translation, MT post-editing, editing, proofreading, localization, transcription and copywriting. I am also undertaking a postgraduate course in Specialized English Translation from University Estácio de Sá.
PROFESSIONAL BACKGROUND - TRANSLATOR
2019 - present: freelance translator for public and private sector, translation agencies and direct clients. Translation of texts in the areas of IT, marketing and life sciences. I also have experience in government/politics, technical/engineering, culinary/cooking, sports, journalism and social sciences.
2019 - present: Embassy News (communication vehicle for embassies and international organizations). Translation from Portuguese into English of news items at website https://embassynews.info/.
2018 - present: Unbabel Translation Community. Translation from English into Portuguese to feed Unbabel's platform "Translation as a Service". The website is: https://unbabel.com/translators/.
2014 - 2018: Ministry of Foreign Affairs of Bangladesh. Protocol assistant for the Embassy of Bangladesh in Brasília. Translation of texts on general topics. Consular and HR support services.
2012 - 2014: Brazilian Federal Senate Translation and Interpretation Service. Internship translator of texts on general and government/politics topics.
ACADEMIC BACKGROUND
2019 - present: postgraduate course in Specialized English Translation from University Estácio de Sá. Topics include: Technical Translation (IT, Life Sciences, culinary/cooking, engineering, etc.), Audiovisual Translation and Translation and New Technologies.
2019 - present: specialization translation course from Brasillis Institute. Topics include: translation of texts on medicine (cardiology, dermatology, endocrinology, pediatrics, pharmacology, surgical instruments, etc.), IT and localization (textbooks on softwares and manuals). Website: http://www.brasillis.com.br/
2017 - 2018: Government exam course - preparation for the Legislative Chamber of the Federal District exam, which took place in September/2018. Topics included: Constitutional Law, Administrative Law, Legislative Chamber of the Federal District Bylaws, Parliamentary Writing, etc.
2010 - 2014: B.A. in Translation from the University of Brasília. Topics included: Linguistics, Latin, Translation Theories and Translation Practices (General/Literary/Scientific).
PROFESSIONAL BACKGROUND - BEFORE TRANSLATION
2014: University of Brasília - English Without Borders Program. Internship at the English Without Borders Program (ISF) from August 2014 to October 2014. I was in charge of giving support to teachers of the Program.
2014: FIFA Broadcast Service Team/ HBS. Internship at the FIFA Broadcast Service Team at the 2014 FIFA World Cup hosted in Brazil from June/14 to July/14. I was in charge of giving support to the FIFA TV Venue Manager and performing post-match activities at the Press Conferences and Mixed Zone.
2013-2014:University of Brasília - Special Needs Support Program. Tutor at the Special Needs Support Program (PPNE). I was in charge of tutoring a fellow translator with special needs.
PERSONAL INTERESTS
Study of Languages
Technology
Culinary and Health
Dance and Music
Literature and Reading
Travel
Sports and Fitness
LANGUAGES
Portuguese: native
English: fluent Certification: ECCE Michigan (2010)
Spanish: intermediate
French: pre-intermediate
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