Source text - Spanish Mitochondrial oxidative phosphorylation (OXPHOS) has been observed to decline with age in association with the accumulation of somatic mtDNA rearrangement and base substitution mutations. These observations have lead to the theory that the mtDNA is the aging clock. To this aging story was added a new twist in a recent issue of PNAS, an mtDNA mutation that promotes longevity.
PNAS 100(5): 2174
Translation - English Se ha observado que la tasa de fosforilación oxidativa mitocondrial (abreviada como OXPHOS en inglés) decrece con la edad, lo cual ha sido asociado a la acumulación de rearreglos del ADNmt y a mutaciones de substitución de bases nucleotídicas. Estas observaciones han derivado en la postulación de la teoría según la cual el ADNmt es el “reloj del envejecimiento”. A esta historia se le ha dado un nuevo giro en una edición reciente de PNAS: una mutación del ADNmt que promueve la longevidad.
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Keywords: science, genetics, molecular biology, environment and ecology, chemistry, ciencia, genetica, biologia molecular, medio ambiente y ecologia, botany, botanica, zoologia, zoology, quimica