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Russian to English: Translation sample 3 General field: Medical Detailed field: Medical: Oncology
Source text - Russian Опорные исследования определения молекулярного профиля опухолей с применением микрочипов ДНК позволили выделить пять внутренних подтипов РМЖ. Хотя на основании результатов иммуногистохимических (ИГХ) исследований подгруппа ТНРМЖ считается единым целым, молекулярное профилирование выявило неожиданно высокий уровень неоднородности. 50–75% ТНРМЖ имеют базальноподобный фенотип (БПРМЖ), характеризующийся экспрессией генов нормальных базальных и миоэпителиальных клеток. Аналогичным образом, около 80% БПРМЖ являются ЭР-негативными и HER2-негативными
Translation - English Pivotal trials of tumour molecular profiling using DNA microarrays have identified five intrinsic subtypes of breast cancer (BC). Although the triple-negative breast cancer (TNBC) subgroup is considered as a single entity based on immunohistochemical (IHC) findings, molecular profiling revealed an unexpectedly high degree of heterogeneity. 50-75% of TNBC cases show a basal-like subtype breast cancer (BLBC) characterised by gene expression of normal basal and myoepithelial cells. Similarly, about 80% of BLBC cases are ER-negative and HER2-negative.
Russian to English: Translation sample 4 General field: Medical Detailed field: Medical: Oncology
Source text - Russian В исследование включены 48 пациенток пожилого возраста с HER2neu отрицательным раком левой молочной железы на этапе 3D конформной лучевой терапии на ложе левой молочной железы СОД 39 Гр (эквивалентна 48 Гр обычного фракционирования). Женщины были отобраны методом случайной выборки из общего числа не имеющих в анамнезе эпизодов нарушений сердечного ритма и не предъявляющих каких-либо характерных для аритмии жалоб больных, госпитализированных в радиотерапевтическое отделение.
Translation - English The study included 48 elderly female patients with HER2/neu negative left breast cancer who were receiving 3D conformal radiotherapy on the left breast tumour bed with a total boost dose (TBD) of 39 Gy, which is equivalent to 48 Gy in conventional fractionation. Women were randomly selected from the total number of patients with no history of both arrhythmia and arrhythmia-specific complaints, who were admitted to the radiotherapy department.
Russian to English: Translation sample 5 General field: Medical Detailed field: Medical: Health Care
Source text - Russian В целом, прогноз для восстановления и занятий спортом после лечения для большинства людей очень благоприятный. При болезни Легга-Кальве-Пертеса кровоснабжение головки бедренной кости нарушается, и клетки костной ткани начинают погибать. Ослабленная костная ткань может разделиться на части, а сама головка — потерять округлую форму. Лечение направлено на удержание головки бедренной кости внутри суставной впадины для сохранения округлой формы головки. Это можно сделать с помощью специальной гипсовой повязки, накладываемой на нижние конечности так, чтобы они было широко разведены, на срок от четырех до шести недель.
Translation - English In general, the prognosis for recovery and sports activity after treatment is very favourable for most people. In Legg-Calve-Perthes disease, the femoral head blood supply is disturbed and bone cells begin to die. The weakened bone tissue may split apart and the head may lose its spherical shape. The treatment is aimed at keeping the head within the glenoid cavity to maintain the femoral head sphericity. This can be done with a special plaster cast placed on the lower limbs as to fix them in a wide spread position for four to six weeks.
Russian to English: Post MT editing sample General field: Medical Detailed field: Medical (general)
Source text - Russian Melatonin (N-acetyl-5-methoxytryptamine) was first isolated at Yale University by Aron Lerner from the bovine epiphysis in 1958 [1].
The maximum level of melatonin in the blood is observed between 24 hours of the night and 5 a.m.
Numerous clinical studies have shown an improvement in the quality of sleep after the administration of exogenous melatonin [15,16].
1 research used intravenous infusions at doses of 0.02 mg (10 mL / h) and 0.023 mg (250 mL / h) [32, 34], respectively.
Oral administration of immediate-release melatonin was evaluated in 17 studies [15, 21, 24, 25, 27-31, 33, 34, 36, 37, 39, 41-43], sustained release - in 1 study [35], with pulsing release (immediate release + secondary release) - in 1 study [42], drugs with prolonged action - in 2 studies [39, 40].
Obtained pharmacokinetic parameters (maximum concentration) C max , time to maximum concentration T max , half-life T 1/2 , area under the pharmacokinetic curve AUC, cli Cl, volume of distribution (V D) , and bioavailability (F) of each study are presented in Table 1.
Translation - English Melatonin (N-acetyl-5-methoxytryptamine) was first isolated from the bovine pineal gland at Yale University by Aron Lerner in 1958 [1].
Maximum blood levels of melatonin occur between 12 a.m. and 5 a.m. (midnight and 5 h).
Numerous clinical studies have shown an improvement in sleep quality after administration of exogenous melatonin [15,16].
One study used intravenous infusions at doses of 0.02 mg (10 mL/h) and 0.023 mg (250 mL/h) [32,34], respectively.
Oral administration of immediate-release melatonin was evaluated in 17 studies [15, 21, 24, 25, 27-31, 33, 34, 36, 37, 39, 41-43], delayed-release in 1 study [35], pulsatile-release (immediate release + secondary release) in 1 study [42], and sustained formulations in 2 studies [39, 40].
The pharmacokinetic parameters (maximum concentration Cmax, time to peak concentration Tmax, half-life T1/2, area under the pharmacokinetic curve AUC, clearance Cl, volume of distribution VD and bioavailability F) obtained from each study are given in Table 1.
Russian to English: Editing sample General field: Medical Detailed field: Medical: Cardiology
Source text - Russian Устройство для экстракорпорального кровообращения – это интегрированная система оксигенатор+резервуар. Целевое применение модуля оксигенации и теплообмена состоит в обеспечении газообмена и терморегуляции во время проведения экстракорпорального кровообращения, в то время как целевым применением венозного резервуара является сбор и фильтрация крови, поступающей из разных источников.
Цели испытания:
1. Оценить эффективность и эксплуатационные характеристики устройства для экстракорпорального кровообращения.
2. Определить соответствие медицинского изделия нормативной документации, а также технической и эксплуатационной документации производителя данного медицинского изделия.
3. Определить качество устройства для экстракорпорального кровообращения, эффективность и безопасность его применения.
Translation - English The extracorporeal circulation (ECC) device is an integrated oxygenator+reservoir system. The intended use of the integral blood oxygenator and heat exchanger is to provide gas exchange and thermoregulation during extracorporeal circulation, while the intended use of the venous reservoir is to collect and filter blood from various sources.
Test objectives:
1. To evaluate the effectiveness and performance of the ECC device.
2. To determine the compliance of the medical device with the manufacturer's regulatory, technical and operational documentation.
3. To evaluate the quality of the ECC device, its efficiency and safety of use.
English to Russian: Translation sample 2 General field: Medical Detailed field: Medical (general)
Source text - English Simeprevir (brand name: Galexos), a NS3/4A protease inhibitor like the already available DAAs telaprevir and boceprevir, was recently approved by Health Canada for the treatment of chronic hepatitis C genotype 1 infection, in combination with peginterferon alfa and ribavirin in adults with compensated liver disease, including cirrhosis, who are treatment-naïve or who have failed previous interferon therapy (peglyated or non-pegylated) with ribavirin.
Translation - Russian Симепревир (торговое название препарата – Galexos), ингибитор протеазы NS3/4A, подобно уже имеющимся лекарственным средствам прямого противовирусного действия, таким как телапревир и боцепревир, недавно был одобрен Министерством здравоохранения Канады для лечения хронического гепатита С с генотипом 1 в комбинации с пегинтерфероном альфа и рибавирином у взрослых с компенсированным заболеванием печени, включая цирроз, не получавших ранее лекарственной терапии или у тех, для кого предыдущая терапия интерфероном (пегилированным или непегилированным) с рибавирином оказалась неуспешной.
English to Russian: Translation sample 1 General field: Medical Detailed field: Medical (general)
Source text - English Multiple sclerosis (MS) is a chronic, multifactorial disease of the central nervous system (CNS), typified by repetitive relapses and/or progression. Oxidative stress is a crucial factor in MS pathogenesis by ameliorating leukocyte migration, contributing to oligodendrocyte damage and axonal injury. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are created in CNS of MS patients mainly by activated macrophages and microglia structures responsible for demyelinisation and axons disruption.
Translation - Russian Рассеянный склероз (РС) – хроническое, многофакторное заболевание центральной нервной системы (ЦНС), характеризующееся многократными рецидивами и (или) прогрессированием. Окислительный стресс является одним из определяющих факторов патогенеза РС, способствуя миграции лейкоцитов, что приводит к повреждению олигодендроцитов и аксонов. Активные формы кислорода и азота образуются в ЦНС пациентов с РС в основном активированными макрофагами и микроглиальными клетками, ответственными за демиелинизацию и деструкцию аксонов.
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Experience
Years of experience: 16. Registered at ProZ.com: Nov 2023.
Adobe Photoshop, AutoCAD, DeepL, memoQ, Microsoft Excel, Microsoft Word, Plunet BusinessManager, SDLX, Smartcat, Trados Studio, XTRF Translation Management System
Specialist areas: • Clinical trials • Pharmacology / Biochemistry • Journal articles (more than half of which are on cardiology and angiology into English) • Medical equipment (X-ray, CT, MRI, PET, US) and consumables • Translation of protocols and reports (IEC 60601, UL, TUV)
• Searching the web for info on topics not available in Russian, formulating new terms. • Compiling project glossaries and obtaining client approval. • Translation & proofreading. • Text naturalisation (making translations sound natural in the target language) if necessary. •
Translation from pidgins (Japanglish, Franglish, Chinglish etc.) with
rewriting of untranslatable paragraphs where the original author wasn't
available to clarify the semantics. • Translation in Trados and clouds (MemSource, SmartCAT).
Since 2015, the majority of translations have been in the above specialist areas. Clients: Roche, Philips, Pentax, 3M, Bio-Rad.
From
2011 to 2015, translations of X-ray and US medical equipment – Philips,
General Electric (approval documentation, risk matrices and assessment;
IEC 60601, UL, TUV protocols and certificates); papers on chemistry and
industrial technology for RusAl, Sibur, Nornickel; translations of
various papers, project summary documents and process specifications for
Skolkovo residents (mainly on chemistry, biology, innovative
technologies in the agricultural sector, veterinary parasitology).
2008-2011
Editor
• Adapting the style to the client's requirements. • Improve text presentation & translator's flow. • Check for terms and abbreviations. • Global correction of terms according to the project glossary. • Compilation of glossaries. • Text naturalisation (making translations sound natural in the target language). • Translation & editing of AutoCAD drawings.
Scope:
Mainly heavy industrial equipment such as compressors, turbines, air
separation / cryogenic units, production automation (Aermec, Air
Products, Siemens, MAN, Pilz) and X-ray systems such as luggage scanning
systems and medical X-ray equipment (Rapiscan, NewTom Giano).
Keywords: medical translations, clinical trials, pharmacology, medical equipment
Expertise