Marginal structural models are a class of statistical models used for causal inference in epidemiology.[1] Such models handle the issue of time-dependent confounding in evaluation of the efficacy of interventions by inverse probability weighting for receipt of treatment. For instance, in the study of the effect of zidovudine in AIDS-related mortality, CD4 lymphocyte is used both for treatment indication, is influenced by treatment, and affects survival. Time-dependent confounders are typically highly prognostic of health outcomes and applied in dosing or indication for certain therapies, such as body weight or lab values such as alanine aminotransferase or bilirubin.